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CCNL1 Antibody

  • 货号：
    CSB-PA986857
  • 规格：
    ￥2024
  • 图片：
    • Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Cyclin-L1 antibody.
    • Western blot analysis of extracts from HepG2 cells, using Cyclin-L1 antibody.
    • Western blot analysis of extracts from HeLa cells (Lane 2), A549 cells (Lane 3) and HepG2 cells (Lane 4), using Cyclin-L1 antiobdy. The lane on the left is treated with systhesized peptide.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CCNL1 Polyclonal antibody
  • Uniprot No.：
    Q9UK58
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human Cyclin-L1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs). Inhibited by the CDK-specific inhibitor CDKN1A/p21. May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC).
  • 基因功能参考文献：
    1. Results suggest that LEKR1-CCNL1 and IGSF21-KLHDC7A gene polymorphisms influence the development of diabetic retinopathy (DR). PMID: 27607899
    2. CCNL1 is the target gene of miR-199b-5p. PMID: 26043836
    3. Data indicate that if the newborn carried a risk allele rs900400 near LEKR/CCNL1, the impact of stress on birth size was stronger. PMID: 22685556
    4. birth weight lowering effect of the C-allele of rs900400 located near LEKR1 and CCNL1 was replicated in the Danish population. Furthermore the C-allele was associated with increased insulin response following oral glucose stimulation PMID: 22073261
    5. Data show low birth weight in Asian Indians is not due to variation near CCNL1/ADCY5, but variant ADCY5 is associated with elevated glucose/decreased insulin response which suggests a common genetic cause of low birth weight and risk of type 2 diabetes. PMID: 21712988
    6. These data demonstrate that there is a fine balance between CCNL1 and TIMP1, which may contribute to breast cancer development. PMID: 21586274
    7. Our results suggest that a genetic variant of ccnl1 leads to symmetric growth restriction from early pregnancy onward PMID: 21307140
    8. Cyclin L1 amplification is associated with uterine cervical carcinoma. PMID: 20721974
    9. variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight PMID: 20372150
    10. role in pre-mRNA splicing PMID: 11980906
    11. Our results indicate that CCNL1 plays a critical role in the loco-regional progression of HNSCC and may serve as an indicator for occult advanced tumour stages. PMID: 15700036
    12. study suggests that cyclin l1 may have a role in RNA processing complex anc ould participate in tumor progression of head and neck squamous cell carcinoma PMID: 16598186
    13. Data show that a green fluorescent protein (GFP) fusion protein of cyclin L1, in contrast to cyclin L2, was not mobile within the nucleus of living COS7 cells. PMID: 17494991
    14. CDK11(p110) interacts physically and functionally with cyclin Lalpha and -beta isoforms and SR proteins to regulate splicing. PMID: 18216018
    15. Cyclin L has been shown to associate with the PITSLRE kinase and is involved in pre-mRNA processing. PMID: 11980906

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  • 亚细胞定位：
    Nucleus speckle. Nucleus, nucleoplasm.
  • 蛋白家族：
    Cyclin family, Cyclin L subfamily
  • 组织特异性：
    Widely expressed. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC).
  • 数据库链接：

    HGNC: 20569

    OMIM: 613384

    KEGG: hsa:57018

    STRING: 9606.ENSP00000295926

    UniGene: Hs.4859