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CCP110 Antibody

  • 货号：
    CSB-PA528588ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA528588ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CCP110 Polyclonal antibody
  • Uniprot No.：
    O43303
  • 基因名：
    CCP110
  • 别名：
    110 kDa centrosomal protein antibody; CCP110 antibody; Centriolar coiled coil protein 110kDa antibody; Centrosomal protein 110 kDa antibody; Centrosomal protein CP110 antibody; Centrosomal protein of 110 kDa antibody; Cep110 antibody; CP110 antibody; CP110_HUMAN antibody; DKFZp781G1416 antibody; FAN antibody; KIAA0419 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Centriolar coiled-coil protein of 110 kDa protein (1-280AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2.
  • 基因功能参考文献：
    1. PLK4 specifically phosphorylates CP110 at the S98 position and is an essential step for centriole assembly. PMID: 28562169
    2. This brief communication reports on a patient with an exceedingly rare "8p11 (eight-p-eleven) myeloproliferative syndrome" (EMS) with CEP110-FGFR1 rearrangement who responded to treatment with the multi-tyrosine kinase inhibitor (TKI) dasatinib PMID: 28242791
    3. In tissues of prostate cancer patients, low CP110 and high miR-129-3p expression levels correlated with metastasi PMID: 26918338
    4. We demonstrated that restoration of CP110 expression in MDA-MB-231 and MCF-7 cells by miR-129 overexpression rendered the cells sensitive to docetaxel. PMID: 26487539
    5. Data show thata combining cyclin-dependent kinase 2 (CDK2) antagonism and ubiquitin thioesterase 33 (USP33) depletion augments anaphase catastrophe via changes in centrosomal protein of 110 kDa (CP110) protein expression. PMID: 26304236
    6. CP110 plays a mechanistic role in response of lung cancer cells to CDK2 inhibition, especially in the presence of activated KRAS mutations. PMID: 25808870
    7. Centrin2 regulates primary ciliogenesis through controlling CP110 levels. PMID: 25753040
    8. Both protein and mRNA levels of ciliogenesis-associated markers CP110, Foxj1, TAp73 were significantly increased in patients with nasal polyps versus those seen in control subjects and were positively correlated with cilia length PMID: 25201258
    9. using human cells, identification of a new mechanism for the regulation of centrosome duplication that requires USP33, a deubiquitinating enzyme that is able to regulate CP110 levels PMID: 23486064
    10. Neurl4 counteracts accumulation of CP110, thereby maintaining normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centres PMID: 22441691
    11. miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics. PMID: 22684256
    12. Cp110 expression in mucosa from patients with chronic rhinosinusitis might contribute to the poor ciliation observed in these patients PMID: 21982113
    13. Study found that loss of Kif24 leads to the disappearance of CP110 from mother centrioles in cycling cells able to form cilia; thus, identifying a centriolar kinesin that specifically remodels a subset of microtubules, thereby regulating cilia assembly. PMID: 21620453
    14. SCF(Cyclin F)-mediated degradation of CP110 is required for the fidelity of mitosis and genome integrity PMID: 20596027
    15. CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication (CP110) PMID: 12361598
    16. These data demonstrate a functional role for CaM binding to CP110 and suggest that CP110 cooperates with CaM and centrin to regulate progression through cytokinesis. PMID: 16760425
    17. CP110 suppresses a cilia assembly program. PMID: 17719545
    18. The transition from centrioles to basal bodies is negatively regulated by CP11 protein. PMID: 17765674
    19. These results suggest that CEP290 cooperates with Rab8a to promote ciliogenesis and that this function is antagonized by CP110. PMID: 18694559
    20. Results suggest that CPAP and CP110 play antagonistic roles in determining the extent of tubulin addition during centriole elongation, thereby controlling the length of newly formed centrioles. PMID: 19481458

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body.
  • 组织特异性：
    Highly expressed in testis. Detected at intermediate levels in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.
  • 数据库链接：

    HGNC: 24342

    OMIM: 609544

    KEGG: hsa:9738

    STRING: 9606.ENSP00000370803

    UniGene: Hs.279912