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CCT2 Antibody

  • 货号：
    CSB-PA004856ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: CCT2 antibody at 5.63μg/ml
      Lane 1: Jurkat whole cell lysate
      Lane 2: NIH/3T3 whole cell lysate
      Lane 3: MCF-7 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 58, 53 kDa
      Observed band size: 58 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA004856ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA004856ESR1HU at dilution of 1:100
    • Immunoprecipitating CCT2 in Jurkat whole cell lysate
      Lane 1: Rabbit control IgG instead of (1μg) instead of CSB-PA004856ESR1HU in Jurkat whole cell lysate. For western blotting, a HRP-conjugated light chain specific antibody was used as the Secondary antibody (1/50000)
      Lane 2: CSB-PA004856ESR1HU (4μg) + Jurkat whole cell lysate (500μg)
      Lane 3: Jurkat whole cell lysate (20μg)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CCT2 Polyclonal antibody
  • Uniprot No.：
    P78371
  • 基因名：
    CCT2
  • 别名：
    99D8.1 antibody; CCT 2 antibody; CCT beta antibody; CCT-beta antibody; CCT2 antibody; CCTB antibody; Chaperonin containing t complex polypeptide 1 beta subunit antibody; Chaperonin containing t complex polypeptide 1 subunit 2 antibody; Chaperonin containing TCP1 subunit 2 antibody; Chaperonin containing TCP1 subunit 2 (beta) antibody; CTP:phosphocholine cytidylyltransferase 2 antibody; Epididymis secretory sperm binding protein Li 100n antibody; HEL S 100n antibody; MGC142074 antibody; MGC142076 antibody; MGC94480 antibody; PRO1633 antibody; T complex protein 1 beta subunit antibody; T complex protein 1 subunit beta antibody; T-complex protein 1 subunit beta antibody; TCP 1 beta antibody; TCP-1-beta antibody; TCPB_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human T-complex protein 1 subunit beta protein (206-535AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IP
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IP 1:200-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
  • 基因功能参考文献：
    1. the novel LCA mutations in CCTbeta and the impact of chaperon disability by these mutations in cellular biology. PMID: 27645772
    2. A role for the TRiC subunits TCP1 and CCT2, and potentially the entire TRiC complex, in breast cancer. PMID: 25704758
    3. Increased expression of CCT2 is associated with tumor progression and the clinical behavior of gallbladder carcinoma. PMID: 23782473
    4. PDCD5 bound the apical domain of the CCTbeta subunit, projecting above the folding cavity without entering it. Like PDCD5, beta-tubulin also interacts with the CCTbeta apical domain, but a second site is found at the sensor loop deep within the folding cavity. PMID: 24375412
    5. PB2 associates with CCT2 as a monomer and the CCT binding site is located in a central region of the PB2 protein. PMID: 20573828
    6. The chaperonin CCT is identified as a novel physiological substrate for p90 ribosomal S6 kinase (RSK) and p70 ribosomal S6 kinase (S6K). PMID: 19332537

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    TCP-1 chaperonin family
  • 数据库链接：

    HGNC: 1615

    OMIM: 605139

    KEGG: hsa:10576

    STRING: 9606.ENSP00000299300

    UniGene: Hs.189772