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CCT5 Antibody

  • 货号：
    CSB-PA004862EA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, K562 whole cell lysate, HepG2 whole cell lysate
      All lanes: CCT5 antibody at 4µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 60, 50 kDa
      Observed band size: 60 kDa
    • Immunofluorescence staining of A549 cells with CSB-PA004862EA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CCT5 Polyclonal antibody
  • Uniprot No.：
    P48643
  • 基因名：
    CCT5
  • 别名：
    CCT 5 antibody; CCT epsilon antibody; CCT-epsilon antibody; CCT5 antibody; CCTE antibody; CCTepsilon antibody; Chaperonin containing T-complex polypeptide 1; subunit 5 antibody; Chaperonin containing TCP 1 epsilon antibody; Chaperonin containing TCP 1 subunit 5 antibody; Chaperonin containing TCP 1 subunit 5 epsilon antibody; Chaperonin containing TCP1 epsilon antibody; Chaperonin containing TCP1 subunit 5 antibody; Chaperonin containing TCP1 subunit 5 epsilon antibody; KIAA0098 antibody; T complex protein 1 epsilon subunit antibody; T complex protein 1 subunit epsilon antibody; T-complex protein 1 subunit epsilon antibody; TCP 1 epsilon antibody; TCP-1-epsilon antibody; TCP1epsilon antibody; TCPE antibody; TCPE_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human T-complex protein 1 subunit epsilon protein (1-270AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CCT5 Antibody (CSB-PA004862EA01HU)，的标记方式是Non-conjugated。对于CCT5 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA004862EB01HU CCT5 Antibody, HRP conjugated ELISA
    FITC CSB-PA004862EC01HU CCT5 Antibody, FITC conjugated
    Biotin CSB-PA004862ED01HU CCT5 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
  • 基因功能参考文献：
    1. CCT5 complex caps mutant mHTT fibrils at their tips and encapsulates mHTT oligomers, providing a structural description of the inhibition of mHTTQ46-Ex1 by CCT5 complex and a shared mechanism of mHTT inhibition between TRiC chaperonin and the CCT5 complex PMID: 25995452
    2. H147R CCT5 was not as efficient in chaperoning these substrates as wild type CCT5. PMID: 25124038
    3. introduction of the truncated human CCT epsilon subunit into yeast cells PMID: 22232265
    4. A missense mutation within the CCT5 gene is associated with autosomal recessive mutilating sensory neuropathy with spastic paraplegia. PMID: 16399879
  • 相关疾病：
    Neuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive (HSNSP)
  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    TCP-1 chaperonin family
  • 数据库链接：

    HGNC: 1618

    OMIM: 256840

    KEGG: hsa:22948

    STRING: 9606.ENSP00000280326

    UniGene: Hs.1600