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CD180 Antibody

  • 货号：
    CSB-PA006289
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of MOUSE-BRAIN cells using CD180 Polyclonal Antibody
    • Western Blot analysis of mouse brain cells using CD180 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q99467
  • 基因名：
  • 别名：
    CD180 antibody; CD180 antigen antibody; CD180_HUMAN antibody; F630107B15 antibody; LY64 antibody; Ly78 antibody; Lymphocyte antigen 64 antibody; lymphocyte antigen 64 radioprotective 105kDa antibody; lymphocyte antigen-64, radioprotective, 105kDa antibody; MGC126233 antibody; MGC126234 antibody; Radioprotective 105 kDa protein antibody; RP105 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CD180.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells.
  • 基因功能参考文献：
    1. Silencing Cd180 results in increased phagocytosis while tempering the production of the proinflammatory cytokine TNF during Borrelia burgdorferi infection. PMID: 29511161
    2. Calcitriol regulates immune genes CD14 and CD180 to modulate LPS responses in human trophoblasts. PMID: 29089453
    3. CD150 and CD180 receptors may modulate transcriptional program in lymphocytic leukemia cells by regulating the transcription factor expression levels PMID: 29284783
    4. Our data strongly support the use of CCR2 and CD180 mRNAs as whole blood pharmacodynamic (PD)biomarkers for BRD4 inhibitors, especially in situations where paired tumor biopsies are unavailable. In addition, they can be used as tumor-based PD biomarkers for hematologic tumors. PMID: 28073847
    5. combination of signals via CD150 and CD180 leads to blocking of pro-survival pathways that may be a restraining factor for neoplastic CLL B cells propagation in more than 50% of CLL cases where these receptors are coexpressed PMID: 28982149
    6. the close association between the increased proportion of CD180-negative B cells and the activation of IFN-alpha signaling in Systemic lupus erythematosus, is reported. PMID: 26277892
    7. CD180 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
    8. By associating with PIM-1L, CD180 can thus obtain autonomous signaling capabilities, and this complex is then channeling inflammatory signals into B cell survival programs PMID: 26555723
    9. Since MEC1 cells are derived from a CLL patient with mutated IGVH genes (M-CLL) negative correlation between CD180 and CD32 expression on cycling MEC1 cells could be limited to M-CLL. PMID: 25879560
    10. we address of monocytes functional status through assessment of the patterns of expression of Fcgamma receptors CD64, CD32, CD16 and CD180 receptor on monocytes from CLL patients and healthy individuals using specific mAbs and flow cytometry. PMID: 25802446
    11. Data indicate that TLR9-signaling as a crucial factor for turning retinoic acid (RA) into a strong stimulator of RP105-mediated B-cell proliferation. PMID: 23103284
    12. IL-4 failed to up-regulate expression of RP105 at the cell surface. In conclusion, the anti-inflammatory actions of IL-4 occur independently of IL-10, RP105, and the kinase activity of RIPK2 PMID: 22484241
    13. Both mouse and human RP105/MD-1 exhibit dimerization of the 1:1 RP105/MD-1 complex, demonstrating a novel organization. PMID: 21959264
    14. Lower mRNA expression of LY64 was detected in gingival tissue of chronic periodontitis patients compared to healthy controls. PMID: 20233331
    15. Data show that CD180, CD284 and CD14 expression is higher on normal B cells than on CD19+ B-cell chronic lymphocytic leukaemia cells. PMID: 20430725
    16. RP105 cross-linkaage enhanced B-lymphocyte proliferation, TLR9 expression, and growth. PMID: 20133206
    17. RP105 regulated TLR4 signaling in dendritic cells PMID: 15852007
    18. Expression of RP105 and TLR4 is altered on PBC monocytes, which appear to be hypersensitive to LPS, resulting in increased secretion of pro-inflammatory cytokines. PMID: 17448566

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Toll-like receptor family
  • 组织特异性：
    Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells.
  • 数据库链接：

    HGNC: 6726

    OMIM: 602226

    KEGG: hsa:4064

    STRING: 9606.ENSP00000256447

    UniGene: Hs.87205