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  4. CD207 Antibody

CD207 Antibody

  • 货号：
    CSB-PA204342
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA204342(CD207 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA204342(CD207 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse skin tissue, Primary antibody: CSB-PA204342(CD207 Antibody) at dilution 1/425, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
  • 其他：

产品详情

  • Uniprot No.：
    Q9UJ71
  • 基因名：
    CD207
  • 别名：
    C type lectin domain family 4 member K antibody; C-type lectin domain family 4 member K antibody; CD 207 antibody; CD207 antibody; CD207 antigen antibody; CD207 antigen; langerin antibody; CD207 molecule antibody; CLC4K_HUMAN antibody; CLEC 4K antibody; CLEC4K antibody; Langerhans cell specific c type lectin antibody; Langerin antibody; RGD1565913 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human CD207
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.
  • 基因功能参考文献：
    1. Binding analysis between purified long and short forms of langerin and a series of keratin sulfate disaccharide components shows that the binding critically requires the 6-sulfation of Gal and that the long form of langerin displays higher affinity than the short form. PMID: 29631057
    2. CD207(+)CD1a(+) cells are circulating in patients with active Langerhans cell histiocytosis, and TSLP and TGF-beta are potential drivers of Langerhans-like cells in vivo. PMID: 28847997
    3. the data provide evidence that human Langerhans cells are able to cross-present antigens after langerin-mediated internalization. PMID: 26456691
    4. Calcium-independent activation of an allosteric network in langerin by heparin oligosaccharides has been reported. PMID: 28198086
    5. Bacterial Polysaccharide Specificity of the Pattern Recognition Receptor Langerin Is Highly Species-dependent PMID: 27903635
    6. Kinetic and Structural Studies of Interactions between Glycosaminoglycans and Langerin PMID: 27447199
    7. We suggest that CD207 gene polymorphisms rs13421115 and rs17718987 increase the risk of development of end-stage renal disease. PMID: 27234728
    8. This study shows that mutations in the Langerin gene are present in the analysed populations at different genotypic and allelic frequencies and further studies should be conducted to verify the role of these mutations in HIV-1 susceptibility. PMID: 24676666
    9. This study is the first to demonstrate that langerin represents an authentic receptor that binds and internalizes influenza A virus to facilitate infection. PMID: 26468543
    10. Data suggest that Langerin (CD207)-mediated binding of Yersinia pestis to antigen-presenting cells (APCs) may promote its dissemination and infection. PMID: 25829141
    11. Langerin binds heparin (HEP)-like oligosaccharides in two different binding sites depending on the ligand size. PMID: 25747117
    12. The s not only show that langerin and caveolin-1 co-localize at the cell membrane and in vesicles but that caveolin-1 mediated HIV-1 uptake is an intrinsic restriction mechanism present in human Langerhans cells that prevents HIV-1 infection. PMID: 25551286
    13. The impact of two carbohydrate recognition domains mutations, W264R and F241L, on langerin structure, function, and Birbeck granules assembly. PMID: 25650933
    14. Langerin is not expressed by freshly isolated CD1c(+) blood DCs but is rapidly induced on CD1c(+) DCs by serum or TGF-beta via an ALK-3-dependent pathway. PMID: 25516751
    15. Cell-sorting experiments demonstrated that IDO1 expression is found in a subset of CD1a(+)CD14(-)langerin(+) cells, expressing CD103 PMID: 25584868
    16. However, the superoxide dismutase C (SodC) protein of the Mycobacterium leprae cell wall was identified as a langerin-reactive ligand. PMID: 25422308
    17. Both phases of HIV transfer from eLCs to T cells were inhibited when eLCs were pretreated with a mAb to langerin CRD or when HIV was pretreated with a soluble langerin trimeric extracellular domain or by a CRD homolog. PMID: 25070850
    18. Altered langerin function in individuals with the linked N288D and K313I polymorphisms may affect susceptibility to infection by microorganisms. PMID: 24217250
    19. binding properties of langerin PMID: 23226363
    20. A langerin-cre recombinase transgenic knockin mouse strain is generated that efficiently targets Langerhans cells and other langerin-positive dendritic cells, in particular, in the dermis and the lung. PMID: 21998450
    21. measles virus receptor on Langergans cells PMID: 21739428
    22. Unlike selective Langerhans cell deficiency, ablation of all langerin-positive dendritic cells abrogates activation of IFN-gamma-producing and cytolytic CD8-positive T cells following gene gun vaccination. PMID: 21187444
    23. Crystal structures of the carbohydrate-recognition domain from langerin bound to oligomannoses, blood group B antigen, and a fragment of beta-glucan reveal binding to mannose, fucose, and glucose by Ca(2+) coordination of hydroxyl groups. PMID: 21112338
    24. Activation of CD8-positive T cells following intradermal plasmid DNA immunization depends on directly transfected langerin-positive dermal dendritic cells and dermal DCs. PMID: 20713888
    25. Trimeric structure of langerin. PMID: 20181944
    26. Langerin mediates diverse functions on Langerhans cells through dual recognition of sulfated as well as mannosylated glycans by its uniquely evolved C-type carbohydrate-recognition domain PMID: 20026605
    27. Langerin is the major fungal pathogen receptor on human Langerhans cells that recognizes pathogenic and commensal fungi. PMID: 20097424
    28. Data show that the expression of CD1a and CD207 is markedly down-regulated in CA epidermis. PMID: 19426597
    29. In a transgenic mouse model, the langerin-expressing subset of CD8alpha-positive dendritic cells is crucially involved in priming and differentiation of responses to cross-presented antigen. PMID: 19923446
    30. langerin was expressed by Langerhans cells PMID: 12352970
    31. Langerin is a potent langerhans cells -specific regulator of membrane superimposition and zippering, representing a key molecule to trace Langerhans cells [Review]. PMID: 14610287
    32. CD1a and langerin have roles in antigen presentation to T cells PMID: 14991068
    33. The Langerin-positive cells strictly colonized the epidermis and no cells were found in the dermis. PMID: 15222130
    34. Expression of mutated Langerin in human fibroblasts induces tubular-like structures that are negative for Birbeck granules-specific antibodies and do not resemble the characteristic structural features of Birbeck granules. PMID: 15816828
    35. Electron microscopy analysis demonstrated a colocalization of human papillomavirus 16 virus-like particles and langerin, which is expressed only by Langerhans cells PMID: 15831940
    36. The effects of the amino acid changes on the activity of langerin were examined by expressing each of the polymorphic forms. PMID: 16567809
    37. Langerin prevents HIV-1 transmission by Langernhans cells. PMID: 17334373
    38. Langerin transgenic mice have substantially reduced numbers of epidermal langerhans cells, demonstrating that TGFbeta1 acts directly on these cells. PMID: 17938236
    39. The carbohydrate-recognition domain of human Langerin was crystallized followed by X-ray analyses to resolutions of 2.5A for apo-Langerin and to 1.6A and 2.1A for the complexes with mannose and maltose, respectively. PMID: 18061677
    40. overproduction, purification and crystallization of the langerin carbohydrate binding domain is reported PMID: 18259063
    41. Immunohistochemical evaluation of langerin expression may have utility in substantiating a diagnosis of Langerhans cell histiocytosis and separating this disorder from other non-Langerhans cell histiocytic proliferations. PMID: 18277880
    42. Transgenic langerin effectively mediates antigen presentation in vivo by targeting its receptor in appropriate mouse dendritic cell subsets of draining lymph nodes and spleen; peptide major histocompatibility I and II complexes persist for days. PMID: 18322168

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  • 相关疾病：
    Birbeck granule deficiency (BIRGD)
  • 亚细胞定位：
    Membrane; Single-pass type II membrane protein. Note=Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.
  • 组织特异性：
    Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues.
  • 数据库链接：

    HGNC: 17935

    OMIM: 604862

    KEGG: hsa:50489

    STRING: 9606.ENSP00000386378

    UniGene: Hs.199731