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CD2BP2 Antibody

  • 货号：
    CSB-PA001438
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of COS7 cells using CD2BP2 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    O95400
  • 基因名：
    CD2BP2
  • 别名：
    CD2 (cytoplasmic tail) binding protein 2 antibody; CD2 antigen (cytoplasmic tail) binding protein 2 antibody; CD2 antigen cytoplasmic tail-binding protein 2 antibody; CD2 cytoplasmic domain-binding protein 2 antibody; CD2 tail-binding protein 2 antibody; CD2B2_HUMAN antibody; Cd2bp2 antibody; FWP010 antibody; LIN1 antibody; Snu40 antibody; U5 snRNP 52K protein antibody; U5-52K antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Monkey
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CD2BP2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly.
  • 基因功能参考文献：
    1. Knockdown of CD2BP2 results in reduced miRNA levels. CD2BP2 stabilizes miRISC and mature miRNAs, maintaining them at levels necessary to properly regulate target gene expression. PMID: 28180320
    2. CD2BP2 is the ligand of the membrane-proximal proline-rich tandem repeat of CD2 in detergent-soluble membrane compartments. PMID: 12426371
    3. there is a function of the GYF domain of CD2BP2 in mediating protein-protein interactions within the spliceosome PMID: 15105431
    4. interaction of CD2BP2 with a tri-snRNP bridging protein (Prp6), coupled with CD2BP2's absence from the tri-snRNP, suggests it might function in tri-snRNP assembly PMID: 15840814
    5. findings indicate that CD2BP2 is not a constitutive binding partner or key regulator of CD2-mediated signaling events PMID: 17906334

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Note=Predominantly nuclear.
  • 数据库链接：

    HGNC: 1656

    OMIM: 604470

    KEGG: hsa:10421

    STRING: 9606.ENSP00000304903

    UniGene: Hs.202677