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CD300A Antibody

  • 货号：
    CSB-PA887023ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA887023ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA887023ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CD300A Polyclonal antibody
  • Uniprot No.：
    Q9UGN4
  • 基因名：
    CD300A
  • 别名：
    CD300 antigen-like family member A antibody; CD300a antibody; CD300a antigen antibody; CD300a molecule antibody; CLM-8 antibody; CLM8_HUMAN antibody; CMRF 35 H9 antibody; CMRF-35-H9 antibody; CMRF35-H antibody; CMRF35-H9 antibody; CMRF35-like molecule 8 antibody; CMRF35H antibody; CMRF35H leukocyte immunoglobulin like receptor antibody; CMRF35H9 antibody; IgSF12 antibody; Immunoglobulin superfamily member 12 antibody; Inhibitory receptor protein 60 antibody; IRC1 antibody; IRC1/IRC2 antibody; IRC2 antibody; IRp60 antibody; Leukocyte membrane antigen antibody; Mast cell derived paired immunoglobulin like receptor 1 antibody; NK inhibitory receptor antibody; Polymeric immunoglobulin receptor 4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human CMRF35-like molecule 8 protein (18-180AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6.
  • 基因功能参考文献：
    1. Results provide an insight into the novel set of paired receptors CD300a and CD300c that are distinctively expressed on CD56(bright) natural killers (NK) cells with varied effector functions and show there differential binding to their ligands phosphatidylethanolamine and phosphatidylserine (PS) resulting in their differential ability to affect CD56(bright) NK cell functions. PMID: 27040328
    2. High CD300A expression is associated with diffuse large B-cell lymphoma. PMID: 26435477
    3. US3 protein kinase of pseudorabies virus triggers the binding of the inhibitory natural killer cell receptor CD300a to the surface of the infected cell, and protects of virus infected cells against natural killer cell-mediated lysis. PMID: 26581992
    4. Overall, these data indicate that CD300a is a novel Dengue virus binding receptor that recognizes phosphatidylethanolamine and phosphatidylserine present on virions and enhance infection. PMID: 26468529
    5. Data show that peroxisome proliferator activator receptor delta (PPARdelta/beta) directly regulates CD300a protein in macrophages. PMID: 24958459
    6. CD300a induction by the hypoxic environment represents a mechanism of regulation of monocyte/macrophage pro-inflammatory responses at pathologic sites PMID: 24131792
    7. interaction with phosphatidylserines inhibits IgE/FcepsilonRI-dependent anaphylactic basophil degranulation PMID: 24815424
    8. The inhibitory receptor CD300a is regulator of monocytes transendothelial migration. PMID: 24058511
    9. SHP-1, but not SHP-2 or the src homology 2 domain containing inositol 5' phosphatase SHIP, was utilized by CD300a for its inhibitory activity. These studies provide new insights into the function of CD300a in tuning T and B cell responses. PMID: 22537350
    10. CD300a is expressed on human peripheral blood basophils and rapidly up-regulated upon cross-linking of IgE/Fc-epsilon-RI and suppresses anaphylactic degranulation. PMID: 22173928
    11. our results indicate that phosphatidylethanolamine and phosphatidylserine are ligands for CD300a, and that this interaction plays an important role in regulating the removal of dead cells. PMID: 22302738
    12. These results indicated that CD300a is a new phosphatidylserine receptor. PMID: 22185693
    13. CD300a blocked TLR4-mediated and TLR9-mediated expression of pro-inflammatory mediators without affecting TLR3-mediated events. PMID: 22043923
    14. Down-regulation of CD300a is associated with HIV infection. PMID: 21482706
    15. CD300a is an inhibitory receptor expressed by human natural killer (NK) cells, but surprisingly, not all NK clones are inhibited in a CD300a-dependent manner. PMID: 20656921
    16. CD300a(+) human Th1 cells tend to be polyfunctional and after stimulation up-regulate Eomes. PMID: 20498708
    17. CMRF35A and CMRF35H have roles in immunoglobulin signaling; CMRF35H is an inhibitory molecule [review] PMID: 12456026
    18. IRp60 is constitutively expressed on mast cells but is down-regulated by eosinophil major basic protein and eosinophil-derived neurotoxin. Cross-linking of IRp60 led to inhibition of IgE-induced degranulation and stem cell factor-mediated survival PMID: 16339535
    19. Human neutrophils from peripheral blood express the ITIM containing CD300a (also known as IRp60 and CMRF-35H) receptor. Co-ligation of CD300a with (FcgammaRIIa) activation receptor inhibited CD32a mediated signalling. PMID: 17588661
    20. CD300a as a novel regulator of Kit in human MC and suggest roles for this receptor as a suppressor of Kit signaling in MC-related disorders. PMID: 18424727

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    CD300 family
  • 组织特异性：
    Expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes.
  • 数据库链接：

    HGNC: 19319

    OMIM: 606790

    KEGG: hsa:11314

    STRING: 9606.ENSP00000353259

    UniGene: Hs.9688