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CDCA3 Antibody

  • 中文名称：
    CDCA3兔多克隆抗体
  • 货号：
    CSB-PA001515
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HepG2 cells using CdcA3 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q99618
  • 基因名：
    CDCA3
  • 别名：
    CDCA3 antibody; C8 antibody; GRCC8 antibody; TOME1Cell division cycle-associated protein 3 antibody; Gene-rich cluster protein C8 antibody; Trigger of mitotic entry protein 1 antibody; TOME-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human CdcA3.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase.
  • 基因功能参考文献：
    1. these results define a tumor-supportive role for CDCA3. PMID: 29627567
    2. Data indicate a miR-375-HOXB3-CDCA3/DNMT3B regulatory circuitry which contributes to leukemogenesis and suggest a therapeutic strategy of restoring miR-375 expression in Acute myeloid leukemia (AML). PMID: 29439669
    3. OY-TES-1 downregulation in liver cancer cells promotes cell proliferation by upregulating CCND2 and CDCA3. PMID: 25673160
    4. High CDCA3 expression is associated with neoplasms. PMID: 25236463
    5. HoxB3 promote prostate cancer progression by upregulating CDCA3 expression. PMID: 23219899
    6. overexpression of CDCA3 occurs frequently during oral carcinogenesis. PMID: 22839099
    7. a repressor element (cell-cycle-dependent element/cell cycle gene homology region) in the vicinity of the transcription start site, and mutations within this element diminished the cell-cycle-dependent transcriptional regulation of Tome-1 PMID: 15733861

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  • 亚细胞定位：
    Cytoplasm, cytosol.
  • 数据库链接：

    HGNC: 14624

    OMIM: 607749

    KEGG: hsa:83461

    STRING: 9606.ENSP00000442068

    UniGene: Hs.524216