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  4. CDCA7 Antibody

CDCA7 Antibody

  • 货号：
    CSB-PA060287
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9BWT1
  • 基因名：
    CDCA7
  • 别名：
    CDCA7 antibody; JPO1Cell division cycle-associated protein 7 antibody; Protein JPO1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CdcA7.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator.
  • 基因功能参考文献：
    1. HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex; immunodeficiency-centromeric instability-facial anomalies syndrome has a defective HELLS and CDCA7 bipartite nucleosome remodeling complex PMID: 29339483
    2. Transcriptome analysis identified Cdca7 as the top down-regulated gene in Zbtb24 homozygous mutant mESCs, which can be restored by ectopic ZBTB24 expression. Finally, we show that this regulation is conserved between species and that CDCA7 levels are reduced in patients carrying ZBTB24 nonsense mutations PMID: 27466202
    3. Missense mutations in CDCA7 cause immunodeficiency-centromeric instability-facial anomalies syndrome type 3. PMID: 26216346
    4. Data indicate that cell division cycle associated 7 protein (Cdca7) is strongly up-regulated in the hemogenic population during embryonic stem cell hematopoietic differentiation in a Notch-dependent manner. PMID: 25385755
    5. The CDCA7 transcription factor regulates cell proliferation. PMID: 24029427
    6. CDCA7 associates with MYC and this association is modulated in a phosphorylation-dependent manner. PMID: 23166294
    7. JPO1/CDCA7 is a unique transcription regulator whose expression is activated by E2F1 as well as c-Myc. PMID: 16580749

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  • 相关疾病：
    Immunodeficiency-centromeric instability-facial anomalies syndrome 3 (ICF3)
  • 亚细胞定位：
    Nucleus. Cytoplasm. Note=Predominantly nuclear with some expression also seen in the cytoplasm. Predominantly cytoplasmic when phosphorylated at Thr-163.
  • 组织特异性：
    Ubiquitous with higher level in thymus and small intestine. Overexpressed in a large number of tumors, in blood from patients with acute myelogenous leukemia (AML) and in chronic myelogenous leukemia (CML) blast crisis.
  • 数据库链接：

    HGNC: 14628

    OMIM: 609937

    KEGG: hsa:83879

    STRING: 9606.ENSP00000306968

    UniGene: Hs.470654