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CDK11A Antibody

  • 货号：
    CSB-PA05204A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: PC-3 whole cell lysate, Rat kidney tissue
      All lanes: CDK11A antibody at 4µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 92, 91, 46, 19, 63, 50 kDa
      Observed band size: 92 kDa
    • IHC image of CSB-PA05204A0Rb diluted at 1:600 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescent analysis of Hela cells using CSB-PA05204A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CDK11A Polyclonal antibody
  • Uniprot No.：
    Q9UQ88
  • 基因名：
    CDK11A
  • 别名：
    CD11A_HUMAN antibody; CDC2L2 antibody; CDC2L3 antibody; CDK11 antibody; CDK11 p110 antibody; CDK11 p46 antibody; CDK11 p58 antibody; CDK11A antibody; Cell division cycle 2 like 2 (PITSLRE proteins) antibody; Cell division cycle 2-like protein kinase 2 antibody; Cell division protein kinase 11A antibody; Cyclin-dependent kinase 11A antibody; Galactosyltransferase-associated protein kinase p58/GTA antibody; p58GTA antibody; PITSLRE antibody; PITSLRE B antibody; PITSLRE protein kinase beta antibody; PITSLRE serine/threonine-protein kinase CDC2L2 antibody; PITSLREB antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human Cyclin-dependent kinase 11A protein (5-216AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CDK11A Antibody (CSB-PA05204A0Rb)，的标记方式是Non-conjugated。对于CDK11A Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA05204B0Rb CDK11A Antibody, HRP conjugated ELISA
    FITC CSB-PA05204C0Rb CDK11A Antibody, FITC conjugated
    Biotin CSB-PA05204D0Rb CDK11A Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:500-1:1000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression.
  • 基因功能参考文献：
    1. CDK11 has a role in human cancers [review] PMID: 27049727
    2. Observational study of gene-disease association. (HuGE Navigator) PMID: 20508983
    3. demonstrates that CDK11(p46) directly interacts with RanBPM in vitro and in human cells PMID: 14511641
    4. the PITSLRE IRES interacts with the Unr protein, which is more prominently expressed at the G2/M stage of the cell cycle PMID: 15330758
    5. CDK11 kinases could be regulated by interaction with 14-3-3 proteins during cell cycle and apoptosis PMID: 15883043
    6. CDK11(p58) is a new interacting protein and a novel regulator of histone acetyltransferase (HAT) HBO1. PMID: 15963510
    7. CDK11p60 can contribute to apoptosis by direct signalling at the mitochondria, thereby amplifying Fas-induced apoptosis in melanoma cells. PMID: 16004605
    8. These findings suggest that CDK11 may contribute to apoptosis by regulating the activity of NOT2 independent of its kinase activity. PMID: 16039607
    9. mitotic CDK11(p58) isoform, but not the CDK11(p110) isoform, associates with mitotic centrosomes PMID: 16462731
    10. CDC2L2 gene may contribute to the susceptibility of type 2 diabetes in the northern Han Chinese population. PMID: 17177267
    11. findings show that, in addition to playing a role in spindle formation and structure, CDK11(p58) is also required for sister chromatid cohesion and the completion of mitosis PMID: 17606997
    12. These data identified a new negative regulatory protein of ERalpha and provided a new pathway by which CDK11(p58) negatively regulated cells. PMID: 19122208
    13. Phosphorylation of the eukaryotic initiation factor 3f by cyclin-dependent kinase 11 during apoptosis. PMID: 19245811
    14. study identified p21 activated kinase 1 (PAK1) as a new CDK11(p58) substrate; mapped a new phosphorylation site of Ser174 on PAK1; results indicated PAK1 may serve as a downstream effector of CDK11(p58) during mitosis progression PMID: 19520772
    15. Observational study of gene-disease association. (HuGE Navigator) PMID: 17177267

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
  • 组织特异性：
    Expressed ubiquitously. Some evidence of isoform-specific tissue distribution.
  • 数据库链接：

    HGNC: 1730

    OMIM: 116951

    KEGG: hsa:728642

    UniGene: Hs.651228