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  4. CDK19 Antibody

CDK19 Antibody

  • 中文名称：
    CDK19兔多克隆抗体
  • 货号：
    CSB-PA005003GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9BWU1
  • 基因名：
    CDK19
  • 别名：
    bA346C16.3 antibody; CDC2 related protein kinase 6 antibody; CDC2-related protein kinase 6 antibody; CDC2L6 antibody; CDK11 antibody; Cdk19 antibody; CDK19_HUMAN antibody; CDK8 like cyclin dependent kinase antibody; Cell division cycle 2 like 6 (CDK8 like) antibody; Cell division cycle 2 like protein kinase 6 antibody; Cell division cycle 2-like protein kinase 6 antibody; Cell division protein kinase 19 antibody; Cyclin dependent kinase (CDC2 like) 11 antibody; Cyclin dependent kinase 11 antibody; Cyclin dependent kinase 19 variant 2 antibody; Cyclin-dependent kinase 11 antibody; Cyclin-dependent kinase 19 antibody; Death preventing kinase antibody; Death-preventing kinase antibody; KIAA1028 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human CDC2L6
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. Genes coregulated by CDK8/19 and NFkappaB include IL8, CXCL1, and CXCL2. PMID: 28855340
    2. Moreover, it identified CDK19 and CDK8 to be specifically overexpressed during prostate cancer progression, highlighting their potential as novel therapeutic targets in advanced prostate cancer. PMID: 27678455
    3. High CDK19 expression is associated with osteosarcoma. PMID: 28416637
    4. On stimulation of TLR9, CDK8/19 positively regulates inflammatory gene transcription in cooperation with NF-kappaB and C/EBPbeta. PMID: 28151579
    5. Data suggest that, during neurogenesis, Mediator complex cyclin-dependent kinases (CDK8, CDK19) interact directly with PRC2 (polycomb repressive complex 2) subunit EZH2 (enhancer of zeste homolog 2), as well as SUZ12 (suppressor of zeste 12 homolog). PMID: 26002960
    6. Mediator-associated kinases CDK8 and CDK19 restrain increased activation of key super-enhancer-associated genes in acute myeloid leukaemia (AML) cells PMID: 26416749
    7. Microarrays identified target genes for each CDK, and we selected six genes: two target genes of CDK8, two target genes of CDK19 and two genes that were targets for both. PMID: 22117896
    8. CDK8 and CDK19, individually interact with PRMT5 and WDR77, and their interactions with PRMT5 cause transcriptional repression of C/EBPbeta target genes. PMID: 23749998
    9. plays a role in mechanisms of transcriptional regulation upon protein phosphorylation. (review) PMID: 20408451

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
  • 数据库链接：

    HGNC: 19338

    OMIM: 614720

    KEGG: hsa:23097

    STRING: 9606.ENSP00000357907

    UniGene: Hs.744895