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CDK5R2 Antibody

  • 货号：
    CSB-PA003663
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HuvEc cells using p39 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q13319
  • 基因名：
    CDK5R2
  • 别名：
    CD5R2_HUMAN antibody; CDK5 activator 2 antibody; Cdk5r2 antibody; Cyclin dependent kinase 5 activator 2 antibody; Cyclin dependent kinase 5 activator isoform p39i antibody; Cyclin dependent kinase 5 regulatory subunit 2 antibody; Cyclin-dependent kinase 5 activator 2 antibody; Cyclin-dependent kinase 5 regulatory subunit 2 antibody; NCK5AI antibody; Neuronal CDK5 activator isoform antibody; p39 antibody; P39I antibody; p39nck5ai antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human p39.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Activator of CDK5/TPKII.
  • 基因功能参考文献：
    1. p39 is essential for recruiting scaffolding protein muskelin to stress fibers. PMID: 25128817
    2. Hepatocellular carcinoma patients with lower p39 expression had poorer overall survival rate than that with high expression. PMID: 20936377
    3. Our data suggest that neurotoxic insults lead to calpain-mediated conversion of p39 to p29, which might contribute to deregulation of Cdk5 PMID: 11784720
    4. role of the CDK5 molecular complex in the genetic etiology of early-onset Alzheimer disease; a yet unknown functional variant in CDK5 or in a nearby gene might lead to increased susceptibility for early-onset Alzheimer disease PMID: 15917097
  • 亚细胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族：
    Cyclin-dependent kinase 5 activator family
  • 组织特异性：
    Brain and neuron specific.
  • 数据库链接：

    HGNC: 1776

    OMIM: 603764

    KEGG: hsa:8941

    STRING: 9606.ENSP00000304250

    UniGene: Hs.158460