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CDK5RAP3 Antibody

  • 货号：
    CSB-PA986354
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA986354(CDK5RAP3 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA986354(CDK5RAP3 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human brain malignant glioma tissue, Human bladder carcinoma tissue, Primary antibody: CSB-PA986354(CDK5RAP3 Antibody) at dilution 1/449, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
  • 其他：

产品详情

  • Uniprot No.：
    Q96JB5
  • 基因名：
    CDK5RAP3
  • 别名：
    C53 antibody; CDK5 activator binding protein C53 antibody; CDK5 activator-binding protein C53 antibody; CDK5 regulatory subunit associated protein 3 antibody; CDK5 regulatory subunit-associated protein 3 antibody; Cdk5rap3 antibody; CK5P3_HUMAN antibody; HSF 27 antibody; HSF27 antibody; IC53 antibody; Ischemic heart CDK5 activator binding protein C53 antibody; LXXLL/leucine zipper containing ARFbinding protein antibody; LZAP antibody; MST016 antibody; OK/SW cl.114 antibody; PP1553 antibody; Protein HSF-27 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human CDK5RAP3
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, in response to endoplasmic reticulum stress. Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation. Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation. Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation. May also play a role in the rupture of the nuclear envelope during apoptosis. May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1. Required for liver development.; (Microbial infection) May be negatively regulated by hepatitis B virus large envelope protein mutant pre-s2 to promote mitotic entry.
  • 基因功能参考文献：
    1. CDK5RAP3 negatively regulates the beta-catenin signaling pathway by repressing GSK-3beta phosphorylation in gastric neoplasms. PMID: 27793695
    2. C53/LZAP protein bound indirectly to the microtubule (MT), and expression of the C53/LZAP cleavage product caused abnormal MT bundling and NE rupture. PMID: 23478299
    3. our findings provide the new evidence that overexpression of CDK5RAP3 promotes HCC metastasis via downregulation of p14(ARF). PMID: 22860085
    4. LZAP may play an important role in hepatocellular carcinoma progression PMID: 22028922
    5. our results strongly suggest that the binding of hepatitis viral pre-S2 LHBs with C53 is a novel negative regulator of the checkpoint response PMID: 21971960
    6. Data indicate that IC53 is a positive mediator for colon cancer progression, and IC53-rs2737 may serve as protection from the onset of colorectal cancer. PMID: 21394385
    7. Nuclear gamma-tubulin interacts with tumor suppressor protein C53 that is involved in regulation of DNA damage PMID: 21465471
    8. the ability of LZAP to alter p38 phosphorylation depended, at least partially, on the p38 phosphatase, Wip1 PMID: 21283629
    9. Findings reveal that CDK5RAP3 is widely overexpressed in hepatocellular carcinoma and that overexpression of CDK5RAP3 promotes HCC metastasis through PAK4 activation. PMID: 21385901
    10. IC53 is a novel gene, mainly expressed in vascular endothelial cells and mediates cell proliferation PMID: 12054757
    11. results strongly indicate that in response to genotoxic stress, Cdk5 activator-binding protein C53(C53) serves as an important regulatory component of DNA damage checkpoint through modulating cyclin dependent kinase 1-cyclin B1 function PMID: 15790566
    12. It is suggested that LZAP can regulate ARF biochemical and biological activity; additionally, LZAP has p53-dependent cell-cycle effects that are independent of ARF. PMID: 16173922
    13. it is concluded that CDK5RAP3, CCNB2, and RAGE genes may be used as a very reliable biomarkers of lung adenocarcinoma PMID: 17549666
    14. LZAP has a role in NF-kappaB regulation and tumor suppression. PMID: 17785205
    15. CDK5 regulatory subunit associated protein 3 promotes checkpoint kinase 1 activation and mitotic entry in both unperturbed cell-cycle progression and DNA damage response. PMID: 19223857
    16. Endothelium-specific overexpression of human IC53 downregulates endothelial nitric oxide synthase activity and elevates systolic blood pressure in mice. PMID: 19541669

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    CDK5RAP3 family
  • 组织特异性：
    Ubiquitously expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 3 is expressed in kidney, liver, skeletal muscle and placenta.
  • 数据库链接：

    HGNC: 18673

    OMIM: 608202

    KEGG: hsa:80279

    STRING: 9606.ENSP00000344683

    UniGene: Hs.20157