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CDKN2AIP Antibody

  • 货号：
    CSB-PA687184
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA687184(CDKN2AIP Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9NXV6
  • 基因名：
    CDKN2AIP
  • 别名：
    Calcium response factor antibody; CARF antibody; CARF_HUMAN antibody; CDKN2A interacting protein antibody; CDKN2A-interacting protein antibody; Cdkn2aip antibody; collaborates/cooperates with ARF (alternate reading frame) protein antibody; Collaborator of ARF antibody; FLJ20036 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Fusion protein of Human CDKN2AIP
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence.
  • 基因功能参考文献：
    1. a comprehensive current understanding into the molecular mechanisms of CARF functions in regulation of DNA damage response, cell cycle checkpoints, cell survival and death signaling pathways. PMID: 28754531
    2. report that CARF (Collaborator of ARF) is a new target of miR-335 that regulates its growth suppressor function by complex crosstalk with other proteins including p16(INK4A), pRB, HDM2 and p21(WAF1) PMID: 27457128
    3. Oncogenic functions of CARF in hepatocellular carcinoma tumorigenesis is a result of activation of beta-catenin/TCF signaling. PMID: 27829235
    4. CARF promotes carcinogenesis in p53-deficient cells by repressing p21WAF1 and promoting cell cycle progression. PMID: 26278998
    5. The results suggest that CARF regulates early steps of pre-rRNA processing during ribosome biogenesis by controlling spatial distribution of XRN2 between the nucleoplasm and nucleolus. PMID: 26531822
    6. CARF regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling. PMID: 24825908
    7. Analysis of indel variations in the human disease-associated genes CDKN2AIP, WDR66, USP20 and OR7C2 in a Korean population. PMID: 22552337
    8. CARF knockdown elicited DNA damage response as evidenced by increased levels of phosphorylated ATM and gammaH2AX, leading to induction of mitotic arrest and eventual apoptosis. PMID: 21052095
    9. CARF may act as a novel key regulator of the p53 pathway at multiple checkpoints PMID: 18555516
    10. cooperates with human p14ARF in activating p53 PMID: 12154087
    11. CARF may exert a vital control on p53-HDM2-p21(WAF1) pathway that is central to the cell cycle control, senescence, and DNA damage response of human cells PMID: 17460193
    12. CARF exerts a vital control on the p53-HDM2-p21WAF1 pathway that is frequently altered in cancer cells. PMID: 18292944
    13. CARF plays a dual role in regulating p53-mediated senescence and apoptosis, the two major tumor suppressor mechanisms. PMID: 19001376

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  • 亚细胞定位：
    Nucleus, nucleoplasm.
  • 蛋白家族：
    CARF family
  • 组织特异性：
    Ubiquitously expressed.
  • 数据库链接：

    HGNC: 24325

    OMIM: 615914

    KEGG: hsa:55602

    STRING: 9606.ENSP00000427108

    UniGene: Hs.592508