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CDKN2C Antibody

  • 货号：
    CSB-PA075339
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA075339(CDKN2C Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA075339(CDKN2C Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    P42773
  • 基因名：
  • 别名：
    CDK6 inhibitor p18 antibody; CDKN 2C antibody; CDKN 6 antibody; Cdkn2c antibody; CDKN6 antibody; CDN2C_HUMAN antibody; Cyclin dependent inhibitor antibody; Cyclin dependent kinase 4 inhibitor C antibody; Cyclin dependent kinase 6 inhibitor antibody; Cyclin dependent kinase 6 inhibitor p18 antibody; Cyclin dependent kinase inhibitor 2C (p18 inhibits CDK4) antibody; Cyclin dependent kinase inhibitor 2C antibody; Cyclin-dependent kinase 4 inhibitor C antibody; Cyclin-dependent kinase 6 inhibitor antibody; INK4C antibody; OTTHUMP00000046546 antibody; p18 antibody; p18 inhibits CDK4 antibody; p18 INK4c antibody; p18 INK6 antibody; p18-INK4c antibody; p18-INK6 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human CDKN2C
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
  • 基因功能参考文献：
    1. Low P18 expression is associated with multiple endocrine neoplasia type 1-related pancreatic neuroendocrine tumors. PMID: 29134609
    2. Cycling hypoxia could induce significant changes in CLDN1 and CLDN7 expression in nasopharyngeal cancer cells, indirectly regulation P18 expression and affecting cell invasion/proliferation. PMID: 28055967
    3. genetic association studies in population in Houston TX: Data suggest that CDKN2C copy number variations are associated with sporadic medullary thyroid carcinoma; these associations include presence of distant metastasis at presentation and decreased overall survival. PMID: 27610696
    4. CDKN2C gene deletion is associated with plasma cell post-transplantation lymphoproliferative disorders. PMID: 27750397
    5. Our study suggests that p18 is a limiting factor for the noncanonical HSC differentiation path in lymphoid lineages. PMID: 27287689
    6. CDKN2C inactivation contributes to the leukemogenesis in acute promyelocytic leukemia. PMID: 27888400
    7. DNA methyltransferase 3A promotes cell proliferation by silencing CDK inhibitor p18INK4C in gastric carcinogenesis PMID: 26350239
    8. Data suggest that cell cycle-dependent kinase inhibitors CDKN2C/p18 and CDKN1A/p21 facilitate cell cycle entry/cell proliferation of quiescent adult human pancreatic beta cells in primary culture (from tissues obtained from organ donors). PMID: 26740620
    9. Mutations in CDKN2C is associated with sporadic parathyroid adenoma. PMID: 24127162
    10. Analysis of B1a lymphocyte phenotypes of p18-deficient C57BL/6 mice finds that p18 is a key regulator of the size of the B1a cell pool. PMID: 22896639
    11. up-regulated HULC promotes proliferation of hepatoma cells through suppressing p18 PMID: 22685290
    12. Data indicate that the role of CDKN2C in the adverse outcome of cases with hemizygous deletion was less certain. PMID: 21994415
    13. results demonstrate for the first time that N-Myc is a downstream target of RET2A signaling, and propose that induction of N-Myc by RET2A is a key step leading to lower p18 levels during MEN2A tumorigenesis PMID: 21112821
    14. conclude that E2F proteins and Sp1 play an important role in the control of p18 expression PMID: 12077144
    15. Deletions in the CDKN2C locus and hypermethylation in the CDKN2C promoter region play a role in ovarian granulosa cell tumorogenesis. PMID: 12203782
    16. p18INK4c may function as a tumor suppressor in Hodgkin lymphoma, and inactivation may contribute to cell cycle deregulation and defective terminal differentiation of the Reed-Sternberg cells. PMID: 14645011
    17. protein kinase C promotes human cancer cell growth through downregulation of p18(INK4c) PMID: 15107819
    18. p18(INK4C) loss may contribute to medulloblastoma formation in children PMID: 16260494
    19. oncogenic RET and loss of p18 cooperate in the multistep tumorigenesis of medullary thyroid carcinoma PMID: 18316595
    20. NaBu-mediated p18( INK4C ) regulation played a role in cell cycle arrest and erythroid differentiation in K562 cells. PMID: 18642058
    21. deletions of CDKN2C are important in the progression and clinical outcome of myeloma PMID: 18829482
    22. P18 is a tumor suppressor gene involved in human medullary thyroid carcinoma and pheochromocytoma PMID: 18942719
    23. Purpose was to investigate genetic alterations of CDKN2C gene in 38 pituitary adenomas. The absence of CDKN2C protein was correlated with LOH of the CDKN2C locus on chromosome 1 and with methylation of the CDKN2C promoter. PMID: 18973139
    24. The down-regulation of p18(INK4C) expression may contribute to the tumorigenesis of pituitary adenomas. PMID: 19401813
    25. p18(INK4C) is a downstream target of GATA3, constrains luminal progenitor cell expansion, and suppresses luminal tumorigenesis in the mammary gland PMID: 19411068
    26. Results identified a molecular basis for CDK inhibitors to exert an antitumor effect in p18-deficient cancers and support the clinical use of CDK inhibitors. PMID: 19509251

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  • 蛋白家族：
    CDKN2 cyclin-dependent kinase inhibitor family
  • 组织特异性：
    Highest levels found in skeletal muscle. Also found in pancreas and heart.
  • 数据库链接：

    HGNC: 1789

    OMIM: 603369

    KEGG: hsa:1031

    STRING: 9606.ENSP00000262662

    UniGene: Hs.525324