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CDKN2D Antibody

  • 货号：
    CSB-PA006485
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    P55273
  • 基因名：
  • 别名：
    CDKN2DCyclin-dependent kinase 4 inhibitor D antibody; p19-INK4d antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human p19.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Interacts strongly with CDK4 and CDK6 and inhibits them.
  • 基因功能参考文献：
    1. p19(INK4d) plays an active role during human tooth development along with MSX1 and MSX2 PMID: 28933666
    2. We unexpectedly found that p19INK4d plays an important role in human terminal erythropoiesis PMID: 27879259
    3. p19(INK4D) is one of the key mediators of miR-125b activity during the onset of megakaryocyte polyploidization. PMID: 27763644
    4. p19 may play an important role in the ototoxic effects of cisplatin and is probably involved in the pathogenesis of hearing loss. PMID: 26722409
    5. MiR-451 inhibited the proliferation of esophageal squamous cell carcinoma cells by targeting CDKN2D and MAP3K1 expression. PMID: 26019450
    6. Data indicate that upon oxidative DNA damage, cyclin-dependent kinase inhibitor p19INK4d strongly binds to and relaxes chromatin. PMID: 25204969
    7. CDKN2D repression by PML/RARalpha disrupts both cell proliferation and differentiation in the pathogenesis of acute promyelocytic leukemia. PMID: 25275592
    8. p19-INK4d inhibits neuroblastoma cell growth, induces differentiation and is hypermethylated and downregulated in MYCN-amplified neuroblastomas. PMID: 25104850
    9. CDKN2D-WDFY2 fusion could be an important molecular signature for understanding and classifying sub-lineages among heterogeneous high-grade serous ovarian carcinomas. PMID: 24675677
    10. Mutations in CDKN2D is associated with sporadic parathyroid adenoma. PMID: 24127162
    11. P19(INK4d) expression is a poor prognostic factor in ovarian cancer patients. PMID: 24022213
    12. PTB plays as a negative regulator in H1299 cell proliferation at least by inducing p19(Ink4d) expression at transcriptional and post-transcriptional levels. PMID: 23536791
    13. Up-regulation of CDKN2D during in-vitro passages of human amniotic fluid-derived mesenchymal stromal cells may indicate the begging of early senescence process in a p53-independent mechanism. PMID: 22747700
    14. E2F1 is involved in the induction of p19INK4d following UV irradiation PMID: 22476863
    15. CDK2 and PKA mediated-sequential phosphorylation is critical for p19INK4d function in the DNA damage response to ensure cell survival. PMID: 22558186
    16. expression of p19INK4D may be an effective predictor of clinical behavior in hepatocellular carcinoma, and therefore, a new prognostic marker PMID: 21901251
    17. p19INK4d is transcriptionally regulated by E2F1 through two response elements present in the p19INK4d promoter. PMID: 21765927
    18. protein folding and stability PMID: 11786024
    19. The human p19(INK4d) gene is under the control of TATA-less promoter and the Sp1 binding site is involved in the transcription. PMID: 12062451
    20. Deletions in the CDKN2D locus and hypermethylation in the CDKN2D promoter region plays a role in ovarian granulosa cell tumorogenesis. PMID: 12203782
    21. p19(INK4d) in addition to p21(WAF1/Cip1) is an important molecular target of HDAC inhibitors inducing growth arrest PMID: 15107822
    22. In addition to its role as cell cycle inhibitor, p19INK4d is involved in maintenance of DNA integrity and, therefore, would contribute to cancer prevention. PMID: 15750620
    23. Data suggest that the graded stability and the facile unfolding of repeats 1 and 2 is a prerequisite for the down-regulation of the inhibitory activity of p19(INK4d) during the cell-cycle. PMID: 17804013
    24. The study shows that mimicking the phosphorylation site of p19INK4d by a glutamate substitution at position 76 dramatically decreases the stability of the native but not an intermediate state. PMID: 19063602

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    CDKN2 cyclin-dependent kinase inhibitor family
  • 数据库链接：

    HGNC: 1790

    OMIM: 600927

    KEGG: hsa:1032

    STRING: 9606.ENSP00000337056

    UniGene: Hs.435051