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  4. CDNF Antibody

CDNF Antibody

  • 中文名称：
    CDNF兔多克隆抗体
  • 货号：
    CSB-PA396777
  • 规格：
    ￥880
  • 图片：
    • Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200
  • 其他：

产品详情

  • Uniprot No.：
    Q49AH0
  • 基因名：
    CDNF
  • 别名：
    Arginine rich mutated in early stage tumors like 1 antibody; ARMET L1 antibody; ARMET like protein 1 antibody; ARMET-like protein 1 antibody; ARMETL 1 antibody; ARMETL1 antibody; CDNF antibody; CDNF_HUMAN antibody; Cerebral dopamine neurotrophic factor antibody; Conserved dopamine neurotrophic factor antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide from Human protein at AA range: 31-80
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 纯化方式：
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC,ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC IHC-p:1:50-300
    ELISA 1:10000-20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra.
  • 基因功能参考文献：
    1. Polymorphisms in CDN,F identified in a Han Chinese population, were associated with increased susceptibility to schizophrenia. PMID: 29298719
    2. In various animal models of Parkinson Disease, CDNF is efficient in protecting and repairing dopaminergic neurons, and it inhibits endoplasmic reticulum stress, euroinflammation, and apoptosis. PMID: 28337696
    3. The results showed that AAV8-CDNF administration significantly improved the motor function and increased the tyrosine hydroxylase (TH) levels in Parkinson's disease rats with mild lesions (2 weeks post lesion), but it had limited therapeutic effects in rats with severe lesions (5 weeks post lesion). PMID: 28622392
    4. Results suggest that CDNF treatment selectively enhances long-term memory consolidation PMID: 25975173
    5. showed that CDNF was able to protect dopaminergic neurons against injury caused by alpha-synuclein oligomers. This advises its use against physiological damages caused by alpha-synuclein oligomers PMID: 26149686
    6. Expression of CDNF in the substantia nigra has an anti-inflammatory effect on experimental Parkinson's disease. PMID: 25511018
    7. Although no CDNF mutations are found in early-onset Parkinson's disease patient samples, a trend towards increased risk for Parkinson's in carriers of the C allele of rs7094179 single nucleotide polymorphism (SNP) is found. PMID: 21320571
    8. expressed in several tissues; might be beneficial for the treatment of Parkinson's disease PMID: 17611540
    9. structures of MANF and CDNF were solved; structure explains why MANF and CDNF are bifunctional; neurotrophic activity may reside in the N-terminal domain and ER stress response in the C-terminal domain PMID: 19258449
    10. Study suggests that there is no association between variants in the CDNF gene and cocaine dependence. PMID: 19429035
    11. Observational study of gene-disease association. (HuGE Navigator) PMID: 19429035

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    ARMET family
  • 组织特异性：
    Widely expressed in neuronal and non-neuronal tissues. In the brain, highest levels in the optic nerve and corpus callosum.
  • 数据库链接：

    HGNC: 24913

    OMIM: 611233

    KEGG: hsa:441549

    STRING: 9606.ENSP00000419395

    UniGene: Hs.559067