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CENPN Antibody

  • 货号：
    CSB-PA595538
  • 规格：
    ￥1100
  • 图片：
    • The image is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA595538(CENPN Antibody) at dilution 1/70. (Original magnification: ×200)
    • The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA595538(CENPN Antibody) at dilution 1/70. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q96H22
  • 基因名：
    CENPN
  • 别名：
    CENPN antibody; C16orf60 antibody; ICEN32 antibody; BM-309Centromere protein N antibody; CENP-N antibody; Interphase centromere complex protein 32 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Fusion protein of Human CENPN
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:100-1:300
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.
  • 基因功能参考文献：
    1. Collectively, these studies clarify how CENP-N and CENP-C decode and stabilize the non-canonical CENP-A nucleosome to enforce epigenetic centromere specification and kinetochore assembly. PMID: 29280735
    2. this study reports cryo-electron microscopy (cryo-EM), biophysical, biochemical, and cell biological studies of the interaction between the CENP-A nucleosome and CENP-N. PMID: 29269420
    3. Study demonstrate that the CENP-L-N complex plays a crucial role at the core of the 16-subunit Constitutive Centromere-Associated Network through interactions with CENP-C and CENP-H-I-KM. PMID: 26698661
    4. CENP-N is bound to kinetochores during S phase and G2, but is absent from kinetochores during mitosis and G1. PMID: 22100916
    5. Data suggest that CENP-N interprets the information encoded within CENP-A nucleosomes and recruits other proteins to centromeric chromatin that are required for centromere function and propagation. PMID: 19543270

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  • 亚细胞定位：
    Nucleus. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres. Kinetochore-bound levels decrease when cells enter mitosis and increase again when cells exit mitosis.
  • 蛋白家族：
    CENP-N/CHL4 family
  • 数据库链接：

    HGNC: 30873

    OMIM: 611509

    KEGG: hsa:55839

    STRING: 9606.ENSP00000377007

    UniGene: Hs.726537