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CENPX Antibody

  • 货号：
    CSB-PA022871LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human thymus tissue using CSB-PA022871LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CENPX Polyclonal antibody
  • Uniprot No.：
    A8MT69
  • 基因名：
    CENPX
  • 别名：
    CENP X antibody; CENP-X antibody; CENPX antibody; CENPX_HUMAN antibody; Centromere protein X antibody; FAAP10 antibody; FANCM interacting histone fold protein 2 antibody; FANCM-interacting histone fold protein 2 antibody; Fanconi anemia associated polypeptide of 10 kDa antibody; Fanconi anemia-associated polypeptide of 10 kDa antibody; MGC14480 antibody; Retinoic acid inducible gene D9 protein homolog antibody; Retinoic acid-inducible gene D9 protein homolog antibody; Stimulated by retinoic acid gene 13 protein homolog antibody; STRA13 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Centromere protein X protein (1-63AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CENPX Antibody (CSB-PA022871LA01HU)，的标记方式是Non-conjugated。对于CENPX Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA022871LB01HU CENPX Antibody, HRP conjugated ELISA
    FITC CSB-PA022871LC01HU CENPX Antibody, FITC conjugated
    Biotin CSB-PA022871LD01HU CENPX Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks. In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure. DNA-binding function is fulfilled in the presence of CENPS, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own.
  • 基因功能参考文献：
    1. MHF prefers branched DNA over dsDNA because it engages two duplex arms. MHF engages DNA forks or various four-way junctions independent of the junction-site structure. The DNA-binding interface of MHF is important for cellular resistance to DNA damage. PMID: 24390579
    2. CENPX assembly in living human cells, revealing a window in S phase and G2 in which de novo assembly of the complex from a soluble precursor occurs through a dynamic exchange mechanism. PMID: 24522885
    3. It discusses current knowledge of the biological roles of CENP-S and CENP-X and how their dual existence may be a common feature of CCAN (constitutive centromere-associated network) proteins. PMID: 24256282
    4. A long, positively charged patch exposed on the surface of the (MHF1-MHF2) complex plays a critical role in double-stranded DNA binding to chromatin. PMID: 23886707
    5. Results identified a centromere protein S (CENP-S)-containing subcomplex that includes the new constitutive kinetochore protein CENP-X [Stra13] PMID: 19620631
    6. Identification of human and mouse homologs of clone D9 of a murine promyelocyte cell line that was upregulated by retinoic acid. PMID: 8839844

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  • 亚细胞定位：
    Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore.
  • 蛋白家族：
    CENP-X/MHF2 family
  • 数据库链接：

    HGNC: 11422

    OMIM: 615128

    KEGG: hsa:201254

    UniGene: Hs.37616