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CEP152 Antibody

  • 货号：
    CSB-PA008298
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HuvEc cells using CEP152 Polyclonal Antibody
    • Immunohistochemistry analysis of paraffin-embedded human lymph node tissue, using CEP152 Antibody. The picture on the right is blocked with the synthesized peptide.
  • 其他：

产品详情

  • Uniprot No.：
    O94986
  • 基因名：
    CEP152
  • 别名：
    Asterless antibody; CE152_HUMAN antibody; Centrosomal protein 152kDa antibody; Centrosomal protein of 152 kDa antibody; Cep152 antibody; FLJ21594 antibody; KIAA0912 antibody; MCPH4 antibody; MCPH9 antibody; Microcephaly primary autosomal recessive 4 antibody; SCKL5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CEP152.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation. Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure. Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Overexpression of CEP152 can drive amplification of centrioles.
  • 基因功能参考文献：
    1. results demonstrate the different roles of Cep192 and Cep152 in MTOC remodeling and a novel regulatory mechanism during meiotic spindle formation in mouse oocytes. PMID: 28970258
    2. both mouse and human Cep63 and Cep152 cooperate to ensure efficient centriole duplication by promoting the accumulation of essential centriole duplication factors upstream of SAS-6 recruitment and procentriole formation. PMID: 23936128
    3. Found that both sc-54 and ab18 antibodies recognize not only Cdk1 but also Cep152 in Western blot and immunofluorescence assays. PMID: 24137814
    4. Loss of the Cep192- or Cep152-dependent interaction with Plk4 resulted in impaired centriole duplication that led to delayed cell proliferation. PMID: 24277814
    5. Cep57, Cep63, and Cep152 are parts of a ring-like complex localizing around the proximal end of centrioles. PMID: 23333316
    6. CEP152 is a genome maintenance protein disrupted in Seckel syndrome PMID: 21131973
    7. Drosophila Asl and human CEP152 are required for the centrosomal loading of Plk4 in Drosophila and CPAP in human cells, respectively PMID: 20852615
    8. CEP152 is a strong candidate for the causal gene underlying MCPH4 and may be an important gene in the evolution of human brain size. PMID: 20598275

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  • 相关疾病：
    Microcephaly 9, primary, autosomal recessive (MCPH9); Seckel syndrome 5 (SCKL5)
  • 亚细胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
  • 蛋白家族：
    CEP152 family
  • 数据库链接：

    HGNC: 29298

    OMIM: 613529

    KEGG: hsa:22995

    STRING: 9606.ENSP00000382271

    UniGene: Hs.443005