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CEP164 Antibody

  • 货号：
    CSB-PA892491LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA892491LA01HU diluted at 1:600 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CEP164 Polyclonal antibody
  • Uniprot No.：
    Q9UPV0
  • 基因名：
    CEP164
  • 别名：
    AI450905 antibody; BC027092 antibody; CE164_HUMAN antibody; Centrosomal protein 164 antibody; Centrosomal protein 164kDa antibody; Centrosomal protein of 164 kDa antibody; Cep164 antibody; D030051D21 antibody; FLJ54767 antibody; KIAA1052 antibody; MGC38792 antibody; mKIAA1052 antibody; NPHP15 antibody; OTTMUSP00000042044 antibody; RGD1560988 antibody; RGD1561243 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Centrosomal protein of 164 kDa protein (1-112AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CEP164 Antibody (CSB-PA892491LA01HU)，的标记方式是Non-conjugated。对于CEP164 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA892491LB01HU CEP164 Antibody, HRP conjugated ELISA
    FITC CSB-PA892491LC01HU CEP164 Antibody, FITC conjugated
    Biotin CSB-PA892491LD01HU CEP164 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1.
  • 基因功能参考文献：
    1. data suggest that CEP164 is not required in the DNA damage response. PMID: 26966185
    2. This study reveals a novel role for CEP164 in the pathogenesis of nephronophthisis, in which mutations cause ciliary defects coupled with DNA damage induced replicative stress, cell death, and epithelial-to-mesenchymal transition PMID: 25340510
    3. Evidence is provided that TTBK2 effectively phosphorylate Cep164 and Cep97 and inhibits the interaction between Cep164 and its binding partner Dishevelled-3 (an important regulator of ciliogenesis) in a kinase activity-dependent manner. PMID: 25297623
    4. data suggest that TTBK2 also acts upstream of Cep164, contributing to the assembly of distal appendages PMID: 24982133
    5. Cep164 is targeted to the apical domain of the mother centriole to provide the molecular link between the mother centriole and the membrane biogenesis machinery that initiates cilia formation. PMID: 23253480
    6. findings indicate that ARL13B, INPP5E, PDE6D, and CEP164 form a distinct functional network that is involved in JBTS and NPHP but independent of the ones previously defined by NPHP and MKS proteins PMID: 23150559
    7. Study identifies by whole-exome resequencing, mutations of MRE11, ZNF423, and CEP164 as causing Nephronophthisis-related ciliopathies. PMID: 22863007
    8. Single nucleotide polymorphisms of CCND2, RAD23B, GRP78, CEP164, MDM2, and ALDH2 genes were significantly associated with development and recurrence of hepatocellular carcinoma in Japanese patients with hepatitis C virus. PMID: 22004425
    9. These data implicate distal appendages in primary cilia formation and identify Cep164 as an excellent marker for these structures. PMID: 17954613
    10. Cep164 is a key player in the DNA damage-activated signaling cascade. PMID: 18283122
    11. Results show that Cep164 knockdown compromises the cell survival upon UV damage, and that UV irradiation significantly enhances the interaction between Cep164 and XPA. PMID: 19197159

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  • 相关疾病：
    Nephronophthisis 15 (NPHP15)
  • 亚细胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus.
  • 组织特异性：
    Expressed in several cell lines.
  • 数据库链接：

    HGNC: 29182

    OMIM: 614845

    KEGG: hsa:22897

    STRING: 9606.ENSP00000278935

    UniGene: Hs.504009