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CEP192 Antibody

  • 货号：
    CSB-PA851560LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA851560LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA851560LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CEP192 Polyclonal antibody
  • Uniprot No.：
    Q8TEP8
  • 基因名：
    CEP192
  • 别名：
    CEP192 antibody; KIAA1569 antibody; PP8407Centrosomal protein of 192 kDa antibody; Cep192 antibody; Cep192/SPD-2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Centrosomal protein of 192 kDa protein (447-711AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CEP192 Antibody (CSB-PA851560LA01HU)，的标记方式是Non-conjugated。对于CEP192 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA851560LB01HU CEP192 Antibody, HRP conjugated ELISA
    FITC CSB-PA851560LC01HU CEP192 Antibody, FITC conjugated
    Biotin CSB-PA851560LD01HU CEP192 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for mitotic centrosome maturation and bipolar spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication. Centrosome-specific activating scaffold for AURKA and PLK1.
  • 基因功能参考文献：
    1. Study shows that the interaction between Cep295 and Cep192 seems to be crucial for the integrity of centriole structure and also for daughter-to-mother centriole conversion. PMID: 27562453
    2. Here we demonstrate that CEP192 also recruits the type one protein phosphatase (PP1) via a highly conserved KHVTF docking motif. PMID: 28188792
    3. Interphase cells depleted of Cep192 display significantly higher levels of centrosome-associated Pericentrin while overexpression of Cep192 reduces the levels of centrosomal Pericentrin. PMID: 24971877
    4. Plk1 promotes centrosome-based bipolar spindle formation by forming two functionally nonredundant complexes with Cep192. PMID: 26012549
    5. Study identifies a Cep192-organized signaling cascade that underlies both centrosome maturation and bipolar spindle assembly. PMID: 25042804
    6. Plk4 is intricately regulated in time and space through ordered interactions with two distinct scaffolds, Cep192 and Cep152, and a failure in this process may lead to human cancer. PMID: 24997597
    7. Loss of the Cep192- or Cep152-dependent interaction with Plk4 resulted in impaired centriole duplication that led to delayed cell proliferation. PMID: 24277814
    8. cooperation between Cep192 and Cep152 is crucial for centriole recruitment of Plk4 and centriole duplication during the cell cycle. PMID: 23641073
    9. By modulating Cep192 levels, PHD1 thereby affects the processes of centriole duplication and centrosome maturation and contributes to the regulation of cell-cycle progression. PMID: 23932902
    10. CEP192 promotes robust mitotic spindle assembly by regulating K63-polyubiquitin-mediated signaling through CYLD. PMID: 22895009
    11. Cep192-mediated mechanism maximizes AurA activity at centrosomes and appears essential for the function of these organelles as primary microtubule -organizing centers. PMID: 21097701
    12. Cep192 stimulates the formation of the scaffolding upon which gamma-tubulin ring complexes and other proteins involved in microtubule nucleation and spindle assembly become functional during mitosis. PMID: 17980596
    13. major regulator of pericentriolar material recruitment, centrosome maturation, and centriole duplication in mammalian cells PMID: 18207742

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Pericentriolar location in mitotic centrosomes.
  • 数据库链接：

    HGNC: 25515

    OMIM: 616426

    KEGG: hsa:55125

    STRING: 9606.ENSP00000427550

    UniGene: Hs.100914