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CEP250 Antibody

  • 货号：
    CSB-PA871581LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescent analysis of Hela cells using CSB-PA871581LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CEP250 Polyclonal antibody
  • Uniprot No.：
    Q9BV73
  • 基因名：
  • 别名：
    CEP250 antibody; CEP2 antibody; CNAP1Centrosome-associated protein CEP250 antibody; 250 kDa centrosomal protein antibody; Cep250 antibody; Centrosomal Nek2-associated protein 1 antibody; C-Nap1 antibody; Centrosomal protein 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Centrosome-associated protein CEP250 protein (40-293AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CEP250 Antibody (CSB-PA871581LA01HU)，的标记方式是Non-conjugated。对于CEP250 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA871581LB01HU CEP250 Antibody, HRP conjugated ELISA
    FITC CSB-PA871581LC01HU CEP250 Antibody, FITC conjugated
    Biotin CSB-PA871581LD01HU CEP250 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be involved in ciliogenesis. Probably plays an important role in centrosome cohesion during interphase.
  • 基因功能参考文献：
    1. C-NAP1-null cells were viable and had an increased frequency of premature centriole separation, accompanied by reduced density of the centriolar satellites, with reexpression of C-NAP1 rescuing both phenotypes. Centrosome amplification induced by DNA damage or by PLK4 or CDK2 overexpression was markedly reduced in the absence of C-NAP1. PMID: 28100636
    2. ASPP1/2 interacted with centrosome linker protein C-Nap1. Co-depletion of ASPP1 and ASPP2 inhibited re-association of C-Nap1 with centrosome at the end of mitosis. PMID: 25660448
    3. multisite phosphorylation precipitates centrosome disjunction at the onset of mitosis PMID: 24695856
    4. A homozygous nonsense CEP250 mutation, in combination with a heterozygous C2orf71 nonsense mutation, causes an atypical form of Usher syndrome, characterised by early-onset sensorineural hearing loss and a relatively mild retinitis pigmentosa. PMID: 24780881
    5. Centlein complexes with C-Nap1 and Cep68 at the proximal ends of centrioles during interphase. PMID: 24554434
    6. C-NAP1 and rootletin restrain DNA damage-induced centriole splitting and facilitate ciliogenesis. PMID: 23070519
    7. Data show that the dissociation of C-Nap1 from mitotic centrosomes is regulated by localized phosphorylation rather than generalized proteolysis. PMID: 12140259
    8. CEP135 acts as a platform protein for C-NAP1 at the centriole. PMID: 18851962

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  • 亚细胞定位：
    Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment. Note=Component of the core centrosome. In interphase cells, it specifically associates with the proximal ends of both mother and daughter centrioles. Associates with the centrosome in interphase cells. In mitotic cells, it dissociates from the mitotic spindle poles. At the end of cell division, it reaccumulates at centrosomes.
  • 组织特异性：
    Ubiquitously and weakly expressed.
  • 数据库链接：

    HGNC: 1859

    OMIM: 609689

    KEGG: hsa:11190

    STRING: 9606.ENSP00000380661

    UniGene: Hs.443976