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CEP68 Antibody

  • 货号：
    CSB-PA765741LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CEP68 Polyclonal antibody
  • Uniprot No.：
    Q76N32
  • 基因名：
  • 别名：
    Centrosomal protein 68kDa antibody; Centrosomal protein of 68 kDa antibody; Cep68 antibody; CEP68_HUMAN antibody; FLJ25920 antibody; FLJ36750 antibody; KIAA0582 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Centrosomal protein of 68 kDa protein (280-480AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CEP68 Antibody (CSB-PA765741LA01HU)，的标记方式是Non-conjugated。对于CEP68 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA765741LB01HU CEP68 Antibody, HRP conjugated ELISA
    FITC CSB-PA765741LC01HU CEP68 Antibody, FITC conjugated
    Biotin CSB-PA765741LD01HU CEP68 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting. Required for localization of CDK5RAP2 to the centrosome during interphase.
  • 基因功能参考文献：
    1. CEP68 is important in forming rootletin filaments that branch off centrioles and to modulate the thickness of rootletin fibers. PMID: 29463719
    2. It has been proposed that the archetypal linker protein Rootletin maintains centrosome cohesion in part through inhibition of VHL-mediated Cep68 degradation. PMID: 28089774
    3. The Cep68 protein level needs to be fine-tuned in order to ensure that its direct interactors, such as the microcephaly protein Cep215 and PCNT, function properly. PMID: 28578000
    4. Cep68 degradation allows Cep215 removal from peripheral pericentriolar material (PCM) preventing centriole separation following disengagement, PCNT cleavage mediates Cep215 removal from core of the PCM to inhibit centriole disengagement and duplication PMID: 25503564
    5. C-terminal 300-400 amino acids of Cep68 are necessary to localize Cep68 to interphase centrosomes while C-terminal 400-500 amino acids might regulate Cep68 dissociation from centrosomes at mitotic onset. PMID: 25704143
    6. CEP68 gene variants may play an important role in MNSAID-UA susceptibility and, despite the different regulatory mechanisms involved depending on the specific affected organ, in the development of hypersensitivity reactions to NSAIDs. PMID: 24618698
    7. Findings imply that CEP68 could be a susceptible gene for aspirin intolerance in asthmatics. PMID: 21072201
    8. our study is the first to identify and validate Endofin, DCBLD2, and KIAA0582 as part of a complex EGF phosphotyrosine signaling network PMID: 17570516
    9. data suggest that Cep68 cooperates with rootletin and C-Nap1 in centrosome cohesion. PMID: 18042621

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 数据库链接：

    HGNC: 29076

    OMIM: 616889

    KEGG: hsa:23177

    STRING: 9606.ENSP00000367229

    UniGene: Hs.709257