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CGGBP1 Antibody

  • 货号：
    CSB-PA070082
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9UFW8
  • 基因名：
    CGGBP1
  • 别名：
    20 kDa CGG binding protein antibody; 20 kDa CGG-binding protein antibody; CGBP1_HUMAN antibody; CGG binding protein 1 antibody; CGG triplet repeat binding protein 1 antibody; CGG triplet repeat-binding protein 1 antibody; CGG-binding protein 1 antibody; CGGBP 1 antibody; CGGBP antibody; Cggbp1 antibody; OTTHUMP00000213853 antibody; OTTHUMP00000213877 antibody; p20 CGG binding protein antibody; p20 CGGBP antibody; p20 CGGBP DNA binding protein antibody; p20-CGGBP DNA-binding protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CGGBP1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter.
  • 基因功能参考文献：
    1. By studying global gene expression patterns and genome-wide DNA-binding patterns of CGGBP1, it has been shown that a possible mechanism through which it affects the expression of RNA Pol II-transcribed genes in trans depends on Alu RNA. PMID: 25483050
    2. CGGBP1 has no direct effect on FMR1 transcription and CGG repeat stability. PMID: 26306647
    3. CGGBP1 protein play an important cytoprotective role in patients with cancer. PMID: 26482656
    4. CGGBP1 is a possible bidirectional regulator of CpG methylation at Alus, and acts as a repressor of methylation at L1 retrotransposons. PMID: 25981527
    5. Our results suggest that CGGBP1 phosphorylation at S164 is a novel telomere protection signal, which can affect telomere-protective function of the shelterin complex PMID: 24196442
    6. Over-expression of miR-7 could significantly inhibit the growth of human lung cancer cells in vivo and in vitro, which might be related to the down-regulated expression of tumor growth-associated protein CGGBP1 PMID: 24491049
    7. CGGBP1 depletion by RNA interference in tumor-derived cells caused an increase in the cell population at G0/G1 phase and reduced the number of cells in the S phase. PMID: 21733196
    8. CGGBP-20 downregulates the activity of 5'-region of FMR1 gene in the presence of GCC-triplets only. PMID: 20141036
    9. CGGBP1 was mapped to chromosome 3p and a sequence of 235 nucleotides 5' upstream of CGGBP1 is essential for promoter activity. PMID: 14667814
    10. Differences in factors implicated in CGG repeat instability--CGG repeat size, XS548/FRAXAC1 haplotypes, and AGG interspersion pattern-are present in the Basque populations analyzed. PMID: 19728537

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Ubiquitous. Highly expressed in placenta, thymus, lymph nodes, cerebellum and cerebral cortex. Low expression in other regions of the brain.
  • 数据库链接：

    HGNC: 1888

    OMIM: 603363

    KEGG: hsa:8545

    STRING: 9606.ENSP00000381428

    UniGene: Hs.444818