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CGN Antibody

  • 货号：
    CSB-PA005302LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA005302LA01HU diluted at 1:800 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CGN Polyclonal antibody
  • Uniprot No.：
    Q9P2M7
  • 基因名：
    CGN
  • 别名：
    6330408J11Rik antibody; AI647528 antibody; AI987749 antibody; cgn antibody; CING_HUMAN antibody; Cingulin antibody; DKFZp779N1112 antibody; FLJ39281 antibody; KIAA1319 antibody; MGC118157 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Cingulin protein (92-252AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CGN Antibody (CSB-PA005302LA01HU)，的标记方式是Non-conjugated。对于CGN Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA005302LB01HU CGN Antibody, HRP conjugated ELISA
    FITC CSB-PA005302LC01HU CGN Antibody, FITC conjugated
    Biotin CSB-PA005302LD01HU CGN Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
  • 基因功能参考文献：
    1. Down-regulation of Cingulin Augments Thrombin-induced Endothelial Barrier Disruption. PMID: 27590342
    2. Cingulin modulates barrier function in endothelium. PMID: 26821949
    3. MgcRacGAP colocalizes with CGN and CGNL1 at TJs and forms a complex and interacts directly in vitro with CGN and CGNL1. PMID: 24807907
    4. Co-imunoprecipitation and confocal microscopy experiments also revealed the tight junction protein cingulin as a new interacting partner of Ubn-1 PMID: 22245583
    5. Results indicate that cells underwent EMT exhibited overactive TGFbeta signaling and loss of expression of the CDH1, CGN, CLDN4, and KLK10 genes as a result of hypermethylation of their corresponding promoter regions. PMID: 20086175
    6. Cingulin (KIAA1319 protein) is localized in the cytoplasmic domain of vertebrate epithelial tight junctions, and it interacts with other tight junction proteins such as ZO-1, and with the actomyosin cytoskeleton. PMID: 11042084

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  • 亚细胞定位：
    Cell junction, tight junction.
  • 蛋白家族：
    Cingulin family
  • 组织特异性：
    Localized on the cytoplasmic face of tight junctions of polarized epithelia and some endothelia. Expressed in pancreas, kidney, liver and lung, but not in skeletal muscle, placenta, brain or heart.
  • 数据库链接：

    HGNC: 17429

    OMIM: 609473

    KEGG: hsa:57530

    STRING: 9606.ENSP00000271636

    UniGene: Hs.591464