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CHST2 Antibody

  • 货号：
    CSB-PA001644
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of Jurkat cells using CHST2 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y4C5
  • 基因名：
    CHST2
  • 别名：
    CHST2 antibody; GN6STCarbohydrate sulfotransferase 2 antibody; EC 2.8.2.- antibody; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 2 antibody; GST-2 antibody; N-acetylglucosamine 6-O-sulfotransferase 1 antibody; GlcNAc6ST-1 antibody; Gn6ST-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human CHST2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains.
  • 基因功能参考文献：
    1. GlcNAc6ST1 is up-regulated in the brains of Alzheimer's disease patients. PMID: 28320965
    2. A method for O-GlcNAc detection using in vitro sulfation with two N-acetylglucosamine (GlcNAc)-specific sulfotransferases, carbohydrate sulfotransferase 2 and carbohydrate sulfotransferase 4. PMID: 24799377
    3. report the sites at which N-Acetylglucosamine-6-sulfotransferase-1 is modified with N-linked glycans and the effects that each glycan has on enzyme activity, specificity, and localization.[N-Acetylglucosamine-6-sulfotransferase-1] PMID: 19571171
    4. is distributed throughout the Golgi apparatus and orchestrates the biosynthesis of L-selectin ligands PMID: 12855678
    5. A novel tumor antigen that is specifically expressed in ovarian mucinous, clear cell and papillary serous adenocarcinomas. PMID: 16897186

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  • 亚细胞定位：
    Golgi apparatus, trans-Golgi network membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Sulfotransferase 1 family, Gal/GlcNAc/GalNAc subfamily
  • 组织特异性：
    Widely expressed. Highly expressed in bone marrow, peripheral blood leukocytes, spleen, brain, spinal cord, ovary and placenta. Expressed by high endothelial cells (HEVs) and leukocytes.
  • 数据库链接：

    HGNC: 1970

    OMIM: 603798

    KEGG: hsa:9435

    STRING: 9606.ENSP00000307911

    UniGene: Hs.529249