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CIAO2A Antibody

  • 货号：
    CSB-PA872502LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: CIAO2A antibody at 8µg/ml + NIH/3T3 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 19, 12 kDa
      Observed band size: 19 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FAM96A Polyclonal antibody
  • Uniprot No.：
    Q9H5X1
  • 基因名：
    FAM96A
  • 别名：
    CIAO2A antibody; CIA2A antibody; FAM96A antibody; Cytosolic iron-sulfur assembly component 2A antibody; MIP18 family protein FAM96A antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Cytosolic iron-sulfur assembly component 2A protein (1-160AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CIAO2A Antibody (CSB-PA872502LA01HU)，的标记方式是Non-conjugated。对于CIAO2A Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA872502LB01HU CIAO2A Antibody, HRP conjugated ELISA
    FITC CSB-PA872502LC01HU CIAO2A Antibody, FITC conjugated
    Biotin CSB-PA872502LD01HU CIAO2A Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component and in collaboration with CIAO1 specifically matures ACO1 and stabilizes IREB2, connecting cytosolic iron-sulfur protein maturation with cellular iron regulation. May play a role in chromosome segregation through establishment of sister chromatid cohesion. May induce apoptosis in collaboration with APAF1.
  • 基因功能参考文献：
    1. our data suggest that hTERTR-FAM96A may serve as an efficient anti-tumor agent for the treatment of hepatocellular carcinoma. PMID: 28443470
    2. FAM96A expression was much reduced in tumorigenic ICC-SCs. PMID: 25716227
    3. CIA2B-CIA1-MMS19 and CIA2A-CIA1 assist different branches of Fe/S protein assembly and intimately link this process to cellular iron regulation via IRP1 Fe/S cluster maturation and IRP2 stabilization. PMID: 23891004
    4. putative metal-binding site of bacterial DUF59 proteins is not conserved in Fam96a, but Fam96a interacts tightly in vitro with Ciao1, the cytosolic iron-assembly protein PMID: 22683786
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    MIP18 family
  • 组织特异性：
    Substantially enriched in macrophages.
  • 数据库链接：

    HGNC: 26235

    KEGG: hsa:84191

    STRING: 9606.ENSP00000300030

    UniGene: Hs.439548