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CISD2 Antibody

  • 货号：
    CSB-PA005443GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8N5K1
  • 基因名：
    CISD2
  • 别名：
    1500009M05Rik antibody; 1500026J14Rik antibody; 1500031D15Rik antibody; AI848398 antibody; B630006A20Rik antibody; CDGSH iron sulfur domain 2 antibody; CDGSH iron-sulfur domain-containing protein 2 antibody; CDGSH type domain 2 antibody; CISD2 antibody; CISD2_HUMAN antibody; Endoplasmic reticulum intermembrane small protein antibody; ERIS antibody; Miner1 antibody; MitoNEET related 1 antibody; MitoNEET-related 1 protein antibody; NAF-1 antibody; Noxp70 antibody; Nutrient deprivation autophagy factor 1 antibody; Nutrient-deprivation autophagy factor-1 antibody; OTTHUMP00000219576 antibody; RGD1566242 antibody; WFS2 antibody; Zcd2 antibody; Zinc finger antibody; Zinc finger; CDGSH type domain 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human CISD2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy.
  • 基因功能参考文献：
    1. CDGSH iron-sulfur domain-containing protein 2 (CISD2) Wolfram syndrome type 2 (WFS2) primary fibroblast cell lines showed consistent reduction in proliferation. PMID: 29239282
    2. CISD2 haploinsufficiency disrupts calcium homeostasis, causing ER stress and subsequent nonalcoholic fatty liver disease and nonalcoholic steatohepatitis PMID: 29166610
    3. CISD2 was increased in glioma samples and was associated with poor prognosis and aggressive tumor behavior. The miR449a/CISD2/beclin1mediated autophagy regulatory network contributed to the proliferation of glioma cells PMID: 28983596
    4. CISD2 is down-regulated in gastric cancer, and its effects on the inhibition of cellular proliferation, metastatic ability, and increased chemotherapy sensitivity are mediated by antagonism to 5-FU-induced autophagy through the AKT/mTOR pathway. PMID: 28857517
    5. The c.103 + 1G > A mutation resulted in the loss of functional CISD2 protein in the two Italian Wolfram syndrome type 2 patients. PMID: 29237418
    6. CISD2 was up-regulated in laryngeal squamous cell carcinoma PMID: 27007153
    7. CISD2 could be an independent prognostic factor for PC and suggested that the CISD2/Wnt/beta-catenin pathway contributed to the proliferation of PC and EMT PMID: 27983920
    8. the patient that we describe in this report with the c.215A > G missense CISD2 variant had the classical features of Wolfram syndrome type 1. The c.215A > G (p.Asn72Ser) variant does not induce CISD2 RNA mis-splicing or a reduction in CISD2 protein levels. Thus, we report a novel missense homozygous CISD2 mutation in a patient with clinical features that differ from previously reported Wolfram syndrome 2 case reports. PMID: 28335035
    9. CISD2 exerts anti-apoptotic and anti-inflammatory effects in neural cells; and (2) curcumin can attenuate the downregulation of CISD2 in SCI and LPS-treated astrocytes. PMID: 26387034
    10. CISD2 protein may serve as a candidate prognostic marker and a novel therapeutic target for hepatocellular carcinoma (HCC) and play an important role in promoting proliferation and enhanced progression of HCC. PMID: 26722601
    11. The findings suggested that CISD2 haplotype-tagging single nucleotide polymorphisms are not associated with Alzheimer's disease risk. PMID: 26154755
    12. NAF-1 is a BCL-2-associated co-factor that targets BCL-2 for antagonism of the autophagy pathway at the endoplasmic reticulum. PMID: 20010695
    13. NAF-1 as a previously unidentified cell target of anti-diabetes thiazolidinedione drugs. PMID: 23717386
    14. provides the first structural information, to our knowledge, for future targeting of the NAF-1-Bcl-2 complex in the regulation of apoptosis/autophagy in cancer biology PMID: 24706857
    15. High CISD2 expression was significantly associated with gastric cancer. PMID: 26565812
    16. NAF-1 is a major player in the metabolic regulation of breast cancer cells. PMID: 26621032
    17. A novel CISD2 mutation is associated with wolfram syndrome 2. PMID: 25371195
    18. Studied the expression pattern and clinicopathological significance of CISD2 in patients with early-stage cervical cancer. PMID: 25134919
    19. Data show that the protein levels of NAF-1 (CISD2) and mNT (CISD1) are elevated in human epithelial breast cancer cells. PMID: 23959881
    20. CISD2 has a role in lifespan control and disease [review] PMID: 20649540
    21. Novel mutation, new phenotypic variant with no diabetes insipidus, presence of peptic ulcer disease, platelet aggregation defect PMID: 14724730
    22. A single missense mutation was identified in a novel, highly conserved zinc-finger gene, ZCD2, in three consanguineous families of Jordanian descent with Wolfram syndrome (WFS). PMID: 17846994
    23. The s show that Miner1 is a homodimer harboring two redox-active 2Fe-2S clusters, indicating for the first time an association of a redox-active FeS protein with Wolfram Syndrome 2. PMID: 19580816

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  • 相关疾病：
    Wolfram syndrome 2 (WFS2)
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein. Note=According to PubMed:20010695, it mainly localizes to the endoplasmic reticulum. However, experiments in mouse showed that it mainly localizes to the mitochondrion outer membrane.
  • 蛋白家族：
    CISD protein family, CISD2 subfamily
  • 组织特异性：
    Testis, small intestine, kidney, lung, brain, heart, pancreas and platelets.
  • 数据库链接：

    HGNC: 24212

    OMIM: 604928

    KEGG: hsa:493856

    STRING: 9606.ENSP00000273986

    UniGene: Hs.444955