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CIT Antibody

  • 货号：
    CSB-PA565862
  • 规格：
    ￥2024
  • 图片：
    • Immunohistochemistry analysis of paraffin-embedded human brain tissue using CTRO antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CIT Polyclonal antibody
  • Uniprot No.：
    O14578
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human CTRO.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:50-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.
  • 基因功能参考文献：
    1. in this study we have provided evidence that ASPM controls spindle orientation by regulating the dynamics of astral MT and that CITK is a critical downstream partner of ASPM for this activity. PMID: 27562601
    2. Control of abscission requires Eph kinase activity, and Src and citron kinase (CitK) are downstream effectors in the Eph-induced signal transduction cascade PMID: 27551053
    3. The striking phenotypic overlap between CIT-mutated individuals and the knockout mice and rats that are specifically deficient in the kinase domain supports the proposed causal link between CIT mutation and primary microcephaly in humans. PMID: 27503289
    4. Splice site variant in CIT, identified in this study, is predicted to abolish splice donor site. cDNA sequence of an affected individual showed retention of an intron next to the splice donor site. The study, presented here, revealed the first variant in the CIT causing Autosomal recessive primary microcephaly in the family. PMID: 27519304
    5. Biallelic Mutations in Citron Kinase Link Mitotic Cytokinesis to Human Primary Microcephaly PMID: 27453578
    6. identification of recessively inherited pathogenic variants in CIT as the genetic basis of severe microcephaly and neonatal death; and postmortem data showing that CIT is critical to building a normally sized human brain PMID: 27453579
    7. The CIT-K may promote this event by interacting with TUBB3 and by recruiting at the midbody casein kinase-2alpha (CK2alpha) that has previously been reported to phosphorylate the S444 residue. PMID: 26586574
    8. Proper midbody architecture requires cross-regulation between two cell division kinases, Citron kinase (CIT-K) and Aurora B, the kinase component of the chromosomal passenger complex. PMID: 27009191
    9. The TPC1 was shown to interact with citron kinase, with TPC1 overexpression affecting RhoA activity and myosin light chain phosphorylation levels in cytokinesis. PMID: 25665131
    10. HIV-1 infection upregulates citK expression at the transcriptional level PMID: 26524911
    11. Data propose that the CC-domain-mediated translocation and actions of Citron-K ensure proper stabilization of the midbody structure during the transition from constriction to abscission. PMID: 23444367
    12. High CIT expression is associated with prostate cancer. PMID: 22761715
    13. p27 has a role in cytokinesis via the regulation of citron-K activity PMID: 22293177
    14. CIT-K is a crucial abscission regulator that may promote midbody stability through active RhoA and anillin. PMID: 21849473
    15. Hrs inhibits HIV-1 production by inhibiting citron kinase-mediated exocytosis. PMID: 21748597
    16. CITRON has a role in proliferation of hepatocellular carcinoma cells PMID: 20369383
    17. Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging. PMID: 20084519
    18. Citron-K has a distinct cell cycle-dependent expression pattern and cellular localization as a downstream target of Rho-GTPase and functions in the control of G(2)/M transition in the hepatocyte cell cycle PMID: 12411428
    19. Single nucleotide polymorphisms associated with bipolar disorder. PMID: 15983625
    20. ASPM and citron kinase co-localize to the midbody ring during cytokinesis. PMID: 17534152

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  • 相关疾病：
    Microcephaly 17, primary, autosomal recessive (MCPH17)
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Protein kinase superfamily, AGC Ser/Thr protein kinase family
  • 数据库链接：

    HGNC: 1985

    OMIM: 605629

    KEGG: hsa:11113

    STRING: 9606.ENSP00000376306

    UniGene: Hs.119594