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CLC Antibody

  • 货号：
    CSB-PA22679A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA22679A0Rb diluted at 1:400 and staining in paraffin-embedded human lymph node tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA22679A0Rb diluted at 1:400 and staining in paraffin-embedded human spleen tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of A549 cells with CSB-PA22679A0Rb at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CLC Polyclonal antibody
  • Uniprot No.：
    Q05315
  • 基因名：
    CLC
  • 别名：
    BSF3 antibody; Charcot Leyden crystal protein antibody; Charcot-Leyden crystal protein antibody; CLC antibody; EC 3.1.1.5 antibody; Eosinophil lysophospholipase antibody; Gal-10 antibody; Galectin-10 antibody; LGALS10 antibody; LGALS10A antibody; LPPL HUMAN antibody; LPPL_HUMAN antibody; Lysolecithin acylhydrolase antibody; MGC149659 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Galectin-10 protein (2-142AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CLC Antibody (CSB-PA22679A0Rb)，的标记方式是Non-conjugated。对于CLC Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA22679B0Rb CLC Antibody, HRP conjugated ELISA
    FITC CSB-PA22679C0Rb CLC Antibody, FITC conjugated
    Biotin CSB-PA22679D0Rb CLC Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).
  • 基因功能参考文献：
    1. findings show that galectin-10 functions as a T cell-suppressive molecule in eosinophils PMID: 28515279
    2. The results support the potential for galectin-10 to be used as a surrogate biomarker of eosinophilic airway inflammation. PMID: 22880030
    3. CLC and IFNAR1 were identified to be overall differentially expressed between early- and late-onset CRC, and are important in the development of early-onset CRC. PMID: 21716316
    4. DK-PGD-induced CLC/Gal-10 mRNA level can serve as a potential marker for monitoring pharmacodynamic effects of blood exposure to CRTH2 modulating agents PMID: 20858065
    5. Genetic variation in Charcot-Leyden crystal protein was found to be associated with allergic rhinitis PMID: 19650845
    6. downregulated significantly in acute myeloid leukemia patients whose white blood cell count was higher than 100 x 10(9)/L cells PMID: 12031912
    7. Changes in the expressions of galectin-10 are potentially important for myeloid cell differentiation into specific lineages. PMID: 12714580
    8. The five genes, and three of the encoded proteins, were shown differentially expressed between a group of keratoconus patients and a reference group using different techniques PMID: 16015083
    9. Downregulated in whole blood of infants hospitalised with respiratory syncytial virus (RSV), subtype B, bronchiolitis. PMID: 17166282
    10. expressed in human T lymphocytes, galectin-10 is essential for the functional properties of CD25(+) Treg cells. PMID: 17502455
    11. Data show that galectin-10 expression was related to the histological grade and with the number of eosinophils in the lesion. PMID: 19758173

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  • 亚细胞定位：
    Cytoplasm, cytosol. Cytoplasmic granule. Note=Localized in granules from where it may be secreted or transported to other locations in the cell.
  • 组织特异性：
    Expressed abundantly in the bone marrow. Expressed exclusively by eosinophils and basophils. Not detected in monocytes and neutrophils. Expressed in CD25-positive regulatory T-cells (Treg) (at protein level). Found in intestinal tissue from patients with
  • 数据库链接：

    HGNC: 2014

    OMIM: 153310

    KEGG: hsa:1178

    STRING: 9606.ENSP00000221804

    UniGene: Hs.889