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CLCA1 Antibody

  • 货号：
    CSB-PA005474LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA005474LA01HU diluted at 1:150 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA005474LA01HU diluted at 1:150 and staining in paraffin-embedded human appendix tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CLCA1 Polyclonal antibody
  • Uniprot No.：
    A8K7I4
  • 基因名：
    CLCA1
  • 别名：
    CaCC antibody; CaCC-1 antibody; CACC1 antibody; Calcium dependent chloride channel 1 antibody; Calcium-activated chloride channel family member 1 antibody; Calcium-activated chloride channel protein 1 antibody; Calcium-activated chloride channel regulator 1 antibody; Chloride channel calcium activated family member 1 antibody; Chloride channel regulator 1 antibody; CLCA family member 1 chloride channel regulator antibody; CLCA1 antibody; CLCA1_HUMAN antibody; CLCRG1 antibody; GOB5 antibody; hCaCC-1 antibody; hCLCA1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Calcium-activated chloride channel regulator 1 protein (715-785AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CLCA1 Antibody (CSB-PA005474LA01HU)，的标记方式是Non-conjugated。对于CLCA1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA005474LB01HU CLCA1 Antibody, HRP conjugated ELISA
    FITC CSB-PA005474LC01HU CLCA1 Antibody, FITC conjugated
    Biotin CSB-PA005474LD01HU CLCA1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.
  • 基因功能参考文献：
    1. Results suggest that CLCA1 is involved in intestinal mucus homeostasis by facilitating processing and removal of mucus to prevent stagnation. PMID: 29885864
    2. CLCA1 suppresses colorectal cancer aggressiveness via inhibition of the Wnt/beta-catenin signaling pathway PMID: 28974231
    3. Increase in TMEM16A activity occurred within minutes of exposure to CLCA1 or after a short treatment with nocodazole, consistent with the hypothesis that CLCA1 stabilizes TMEM16A at the cell surface by preventing its internalization. PMID: 28420732
    4. Data show that calcium-activated chloride channel regulator 1 (CLCA1) and transmembrane protein 16A (TMEM16A) co-localize and physically interact and that CLCA1 increases the level of TMEM16A protein at the cell surface. PMID: 25781344
    5. inhibitor and siRNA transfection studies demonstrated an apparent effect of CLCA1 on ovarian cancer cell aggregation PMID: 26004777
    6. Results confirmed that the low expression of CLCA1 in CRC was associated with tumorigenesis, early metastasis, and high chromosomal instability. Low expression of CLCA1 predicts recurrence and lower survival. PMID: 25603912
    7. These findings demonstrate the ability of hCLCA1 to function as a signaling molecule and activate macrophages, central regulators of airway inflammation. PMID: 24349445
    8. CLCA1 may contribute to promoting spontaneous differentiation and reducing proliferation of Caco-2 cells. PMID: 23593331
    9. CLCA1 expression is significantly related to mucus production in the airway epithelia of smokers and COPD patients, and may contribute to the development and pathogenesis of COPD by inducing mucus production. PMID: 22731784
    10. These data provide both a mechanistic basis for CLCA1 self-cleavage and a novel mechanism for regulation of chloride channel activity specific to the mucosal interface. PMID: 23112050
    11. Increased expression of hCLCA1 in allergic rhinitis was correlated with the expression of MUC5AC. PMID: 20464982
    12. in cultured nasal airway cells, Th2 type cytokines increased hCLCA1 (calcium-activated chloride channel 1) expression in Cystic Fibrosis patients but not mucus expression PMID: 20542744
    13. The 357SS genotype was significantly overrepresented in both patients with meconium ileus and also with a severe CFTR genotype (P = 0.009) and in p.F508del homozygotes (P = 0.002). PMID: 20179644
    14. upregulation in the IL-9- responsive mucus-producing epithelium of asthmatic subjects supports the hypothesis that this channel may be responsible, in part, for the overproduction of mucus in asthmatic subjects PMID: 11842292
    15. transfection of Caco-2 human colon carcinoma cell line with pCLCA1 to investigate the regulation of CLCA-associated chloride conductance in this differentiated epithelial cell line PMID: 12408984
    16. hCLCA1 expression in NCI-H292 cells specifically induces soluble gel-forming mucin production. This Ca2+-activated Cl- channel plays an important role in epithelial-regulated inflammatory responses, including goblet cell metaplasia. PMID: 12568493
    17. polymorphisms in chronic obstructive pulmonary disease PMID: 14985398
    18. Variation of the CLCA1 gene affects patients' susceptibility for childhood and adult asthma in a Japanese population. PMID: 15318163
    19. CLCA1 and CLCA4 may have roles as modulators of the gastrointestinal basic defect in cystic fibrosis PMID: 15490240
    20. conclude that hCLCA1 and mCLCA3 are non-integral membrane proteins and therefore cannot be chloride channels in their own right PMID: 15919655
    21. We successfully cloned a rat brain CLCA (rbCLCA). PMID: 16023076
    22. CACC play a direct role in mucus production by goblet cells and may thus contribute to the pathogenesis of asthma. PMID: 16148052
    23. IL-13 might induce the expression of MUC5AC and hCLCA1 gene and protein in well-differentiated NHBE cells. These cells might also differentiate into goblet cells and become hyperplastic PMID: 16465045
    24. Evidence is given for a role of the CLCA1 hydrolase domain in processing of mature full-length CLCA1 PMID: 16470849
    25. CLCA1 may be a key signaling member that can be targeted with pharmacologic interventions to treat mucus hypersecretion. PMID: 17426222
    26. These data suggest that hCLCA1 may play a role in LPS-induced mucin expression in human airway mucosa. PMID: 17621552
    27. These results suggest that the up-regulated gene expression of CaCC1 exists, which is complicated with mucus hyper-secretion in Chinese asthmatic airway. PMID: 17698377
    28. hClCa1 does not form Ca(2+)-dependent Cl- channels per se. hClCa1 elevates the single channel conductance of endogenous Ca(2+)-dependent Cl- channels by lowering the energy barriers for ion translocation through the pore. PMID: 19307298
    29. genetic polymorphism is associated with childhood asthma PMID: 19530997

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  • 亚细胞定位：
    Secreted, extracellular space. Cell membrane; Peripheral membrane protein; Extracellular side. Note=Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli.
  • 蛋白家族：
    CLCR family
  • 组织特异性：
    Highly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet cells, and appendix. Weakly expressed in uterus, testis and kidney. Expressed in the airways epithelium of both asthmatic and healthy patients. Expressed i
  • 数据库链接：

    HGNC: 2015

    OMIM: 603906

    KEGG: hsa:1179

    STRING: 9606.ENSP00000234701

    UniGene: Hs.194659