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CLCA2 Antibody

  • 货号：
    CSB-PA005475GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9UQC9
  • 基因名：
    CLCA2
  • 别名：
    CLCA2 antibody; CACC3Calcium-activated chloride channel regulator 2 antibody; EC 3.4.-.- antibody; Calcium-activated chloride channel family member 2 antibody; hCLCA2 antibody; Calcium-activated chloride channel protein 3 antibody; CaCC-3 antibody; hCaCC-3) [Cleaved into: Calcium-activated chloride channel regulator 2 antibody; 109 kDa form; Calcium-activated chloride channel regulator 2 antibody; 35 kDa form] antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human CLCA2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4.
  • 基因功能参考文献：
    1. we found by calcium imaging that CLCA2 moderately enhanced intracellular-store release but dramatically increased store-operated entry of calcium upon cytosolic depletion PMID: 29758025
    2. CLCA2 links junctional adhesion molecule EVA1, to cytosolic signaling proteins that modulate proliferation and differentiation. PMID: 26930581
    3. CLCA2 expression is higher in squamous cell carcinoma of the lung compared with adenocarcinoma. PMID: 25548429
    4. Variants in CLCA2 were associated with an ileal involvement phenotype of Crohn's disease. PMID: 25557950
    5. These results strongly suggest that CLCA2 is involved in the p53 tumor suppressor network and has a significant effect on cell migration and invasion. PMID: 22990203
    6. hCLCA2 is required for epithelial differentiation, and its loss during tumor progression contributes to metastasis. PMID: 21909135
    7. the reduced expression of CLCA2 was frequently observed in various kinds of cancers including prostate cancer PMID: 22431922
    8. Expression of hSK4 as well as hCACC-2 and hCACC-3 but not hCACC-1 was demonstrated by reverse transcriptase PCR on native nasal tissues. PMID: 12612194
    9. immunohistochemistry clearly demonstrated colocalisation between hCLCA2 and integrin beta4 PMID: 15707651
    10. human CLCA2 protein and mRNA expression are elevated during epithelial stratification, suggesting that this protein plays a role in the growth of multi-layered corneal epithelia during both natural development and tissue cultivation. PMID: 16158324
    11. Mostly extracellular with only a single transmembrane segment, unlikely to form a channel. PMID: 16873362
    12. hCLCA2 Is a p53-Inducible Inhibitor of Breast Cancer Cell Proliferation. PMID: 19654313

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Basal cell membrane; Single-pass type I membrane protein. Cell junction.; [Calcium-activated chloride channel regulator 2, 109 kDa form]: Secreted. Note=Remains associated to the 35 kDa form until an unidentified event triggers the release.
  • 蛋白家族：
    CLCR family
  • 组织特异性：
    Expressed in cornea, skin, vagina, esophagus, and larynx (at protein level). Expressed in trachea and mammary gland. Weakly expressed in testis and kidney. Highly expressed in corneal epithelium, colon and trachea. Moderately expressed in brain, urogenita
  • 数据库链接：

    HGNC: 2016

    OMIM: 604003

    KEGG: hsa:9635

    STRING: 9606.ENSP00000359596

    UniGene: Hs.241551