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CLCF1 Antibody

  • 货号：
    CSB-PA906951
  • 规格：
    ￥880
  • 图片：
    • Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200
  • 其他：

产品详情

  • Uniprot No.：
    Q9UBD9
  • 基因名：
    CLCF1
  • 别名：
    B cell stimulating factor 3 antibody; B-cell-stimulating factor 3 antibody; BSF 3 antibody; BSF-3 antibody; BSF3 antibody; Cardiotrophin like cytokine antibody; Cardiotrophin like cytokine factor 1 antibody; Cardiotrophin-like cytokine factor 1 antibody; CISS 2 antibody; CISS2 antibody; CLC antibody; CLCF 1 antibody; Clcf1 antibody; CLCF1_HUMAN antibody; Cold induced sweating syndrome 2 antibody; CRLF 1 associated cytokine like factor 1 antibody; CRLF1 associated cytokine like factor 1 antibody; Neurotrophin 1 antibody; Neurotrophin 1/B cell stimulating factor 3 antibody; Neurotrophin1 antibody; NNT 1 antibody; NNT-1 antibody; Novel neurotrophin 1 antibody; Novel neurotrophin-1 antibody; NR 6 antibody; NR6 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide from Human protein at AA range: 171-220
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 纯化方式：
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC,ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC IHC-p:1:50-300
    ELISA 1:10000-20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    In complex with CRLF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). Also stimulates B-cells. Binds to and activates the ILST/gp130 receptor.
  • 基因功能参考文献：
    1. CLF-1, based on its binding site for CLC and on two additional and independent sites for CNTFRalpha and sorLA, is a key player in CLC and CNTFRalpha signaling and turnover. PMID: 26858303
    2. Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative disorders. PMID: 26198769
    3. albuminuria in focal segmental glomerulosclerosis is related to qualitative or quantitative changes in the CLCF1-CRLF1 complex. PMID: 25843671
    4. activation of the Jak-STAT cascade is essential for corticotroph NNT-1/BSF-3 signaling. PMID: 12639901
    5. Structural and docking interaction studies showed that the R197L substitution destabilized the contact site between CLC and CNTFRalpha. PMID: 16782820
    6. Ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin share a conserved binding site on the ciliary neurotrophic factor receptor alpha chain PMID: 18728012

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  • 相关疾病：
    Cold-induced sweating syndrome 2 (CISS2)
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    IL-6 superfamily
  • 组织特异性：
    Expressed predominantly in lymph nodes, spleen, peripheral blood lymphocytes, bone marrow, and fetal liver.
  • 数据库链接：

    HGNC: 17412

    OMIM: 607672

    KEGG: hsa:23529

    STRING: 9606.ENSP00000309338

    UniGene: Hs.502977