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CLEC10A Antibody

  • 货号：
    CSB-PA811601LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA811601LA01HU diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of HepG2 cells with CSB-PA811601LA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CLEC10A Polyclonal antibody
  • Uniprot No.：
    Q8IUN9
  • 基因名：
    CLEC10A
  • 别名：
    C type (calcium dependent carbohydrate recognition domain) lectin superfamily member 13 (macrophage derived) antibody; C type (calcium dependent carbohydrate recognition domain) lectin superfamily member 14 (macrophage derived) antibody; C type lectin domain family 10; member A antibody; C type lectin superfamily member 14 antibody; C-type lectin domain family 10 member A antibody; C-type lectin superfamily member 14 antibody; CD301 antibody; CD301 antigen antibody; CD301A antibody; CLC10_HUMAN antibody; CLEC10A antibody; CLECSF13 antibody; CLECSF14 antibody; HML antibody; HML2 antibody; Lectin antibody; Macrophage C type lectin antibody; MACROPHAGE GALACTOSE-TYPE C-TYPE antibody; Macrophage lectin 2 (calcium dependent) antibody; Macrophage lectin 2 antibody; MGL antibody; Mgl1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human C-type lectin domain family 10 member A protein (66-316AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CLEC10A Antibody (CSB-PA811601LA01HU)，的标记方式是Non-conjugated。对于CLEC10A Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA811601LB01HU CLEC10A Antibody, HRP conjugated ELISA
    FITC CSB-PA811601LC01HU CLEC10A Antibody, FITC conjugated
    Biotin CSB-PA811601LD01HU CLEC10A Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells.
  • 基因功能参考文献：
    1. this paper shows that key gene of intermediate proinflammatory monocytes, such as CLEC10A, is expressed three- to fourfold more in juvenile idiopathic arthritis-enthesitis-related arthritis PMID: 27706807
    2. BRAF(V600E) mutation induces MGL ligand expression, thereby providing a direct link between oncogenic transformation and aberrant expression of immunosuppressive glycans in colorectal neoplasms. PMID: 26172302
    3. These results indicate a role of MGL as an immunomodulator within the tumour microenvironment interfering with Treg functions, suggesting its possible use in the design of anticancer vaccines. PMID: 26147970
    4. expression of GalNAc moieties mirrors the T cell activation status, and thus only highly stimulated T cells are prone to the suppressive action of MGL. PMID: 23918927
    5. MGL triggering synergized with TLR2-induced pathways, leading to elevated IL-10 mRNA levels & enhanced TNF-alpha mRNA stability. It promoted phosphorylation of the ERK & CREB, fine-tuning the DC maturation phenotype. PMID: 23744646
    6. Described is the use of recombinant CLEC10A (CD301), a human glycoreceptor of the C-type lectin family, for the detection of ligands in sections from formalin-fixed, paraffin-embedded normal and cancerous mammary tissues. PMID: 23275449
    7. MGL engagement improved DC performance as antigen-presenting cells, promoting the upregulation of maturation markers, a decrease in phagocytosis, an enhancement of motility, and most importantly an increase in antigen-specific CD8(+) T-cell activation. PMID: 22531918

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  • 亚细胞定位：
    Membrane; Single-pass type II membrane protein.
  • 数据库链接：

    HGNC: 16916

    OMIM: 605999

    KEGG: hsa:10462

    STRING: 9606.ENSP00000254868

    UniGene: Hs.54403