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CLIC3 Antibody

  • 货号：
    CSB-PA037677
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from K562 cells, using CLIC3 antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CLIC3 Polyclonal antibody
  • Uniprot No.：
    O95833
  • 基因名：
    CLIC3
  • 别名：
    CLIC3; Chloride intracellular channel protein 3
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human CLIC3.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Can insert into membranes and form chloride ion channels. May participate in cellular growth control.
  • 基因功能参考文献：
    1. CLIC3 is also secreted by cancer cells, is abundant in the stromal and tumour compartments of aggressive ovarian cancers and its levels correlate with poor clinical outcome. PMID: 28198360
    2. in malignant pleural mesothelioma, the gene expressions of CLIC3 and CLIC4 were significantly increased compared to controls PMID: 26445368
    3. CLIC3 controls trafficking of late endosomal MT1-MMP and dictates invasion and metastasis in breast cancer. PMID: 25015290
    4. results suggest that increased expression of chloride intracellular channel 3 (CLIC3) may play a role in abnormal placental function associated with the human pregnancy disorders fetal growth restrict and pre-eclampsia PMID: 22795578
    5. The structure of the soluble form of CLIC3, is presented. PMID: 20146363
    6. CLIC3 facilitates chloride ion movement and regulates cellular processes associated with the movement of chloride in placental and fetal membrane cells. PMID: 17027078

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  • 亚细胞定位：
    Nucleus. Membrane; Single-pass membrane protein. Cytoplasm.
  • 蛋白家族：
    Chloride channel CLIC family
  • 组织特异性：
    Detected in placenta (at protein level). Widely expressed. High expression is found in placenta followed by lung and heart. Low expression in skeletal muscle, kidney and pancreas.
  • 数据库链接：

    HGNC: 2064

    OMIM: 606533

    KEGG: hsa:9022

    STRING: 9606.ENSP00000419378

    UniGene: Hs.64746