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CLINT1 Antibody

  • 货号：
    CSB-PA005552LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA005552LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA005552LA01HU at dilution of 1:100
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate, Rat liver tissue, Mouse liver tissue
      All lanes: CLINT1 antibody at 2μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 69, 71 kDa
      Observed band size: 69 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CLINT1 Polyclonal antibody
  • Uniprot No.：
    Q14677
  • 基因名：
    CLINT1
  • 别名：
    Clathrin interacting protein antibody; Clathrin interactor 1 antibody; Clathrin-interacting protein localized in the trans-Golgi region antibody; CLINT 1 antibody; Clint antibody; CLINT1 antibody; ENTH antibody; Enthoprotin antibody; EPN4 antibody; EPN4_HUMAN antibody; Epsin 4 antibody; Epsin related protein antibody; Epsin-4 antibody; Epsin-related protein antibody; EpsinR antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human Clathrin interactor 1 protein (1-625AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CLINT1 Antibody (CSB-PA005552LA01HU)，的标记方式是Non-conjugated。对于CLINT1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA005552LB01HU CLINT1 Antibody, HRP conjugated ELISA
    FITC CSB-PA005552LC01HU CLINT1 Antibody, FITC conjugated
    Biotin CSB-PA005552LD01HU CLINT1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:200-1:3000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly.
  • 基因功能参考文献：
    1. Although epsinR has been shown to be a cargo adaptor, the present study indicates that it is an order of magnitude more abundant in CCVs than its known cargo protein, vti1b, suggesting that it may have other functions as well. PMID: 26179914
    2. These results do not support a significant role of GRIA1 or CLINT1 in the development of schizophrenia in the German population. PMID: 21116212
    3. a novel clathrin-associated protein identified through subcellular proteomics; data suggest a role in clathrin-mediated budding on internal membranes PMID: 12213833
    4. might participate in the formation of clathrin-coated vesicles at the level of the trans-Golgi network and remains associated with the vesicles longer than clathrin and adaptors PMID: 12429846
    5. EpsinR is an ENTH domain-containing protein that interacts with AP-1 PMID: 12589059
    6. Our work reveals the existence of clathrin-independent and -dependent transport steps in the retrograde route, and establishes a function for clathrin and epsinR at the endosome-TGN interface. PMID: 15068792
    7. epsinR is an adaptor for vesicle-associated soluble NSF attachment protein receptor PMID: 15371541
    8. Four adjacent markers at the 5' end of the Epsin 4 gene showed significant evidence of linkage disequilibrium with schizophrenia. PMID: 15793701
    9. Results indicate the presence of a locus near the 5' end of Epsin 4 conferring susceptibility to the disease and provide further support for Epsin 4 as an important potential contributor to genetic risk in schizophrenia. PMID: 16402136
    10. characterization of the molecular details governing the sorting of a SNARE into clathrin-coated vesicles, namely the direct recognition of the three-helical bundle H(abc) domain of the mouse SNARE Vti1b by the human clathrin adaptor epsinR PMID: 18033301
    11. Our results suggest that the examined region of Epsin 4 does not have a major influence on susceptibility to schizophrenia in Japanese. PMID: 18696005
    12. Variation in the Epsin 4 gene is significantly associated with psychotic disorder in this Latino population PMID: 18929466

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Membrane; Peripheral membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Found throughout the cell, with the exception of the cell surface. Concentrated in the perinuclear region and associated with clathrin-coated vesicles close to the trans-Golgi network.
  • 蛋白家族：
    Epsin family
  • 组织特异性：
    Ubiquitously expressed at low to intermediate levels.
  • 数据库链接：

    HGNC: 23186

    OMIM: 607265

    KEGG: hsa:9685

    STRING: 9606.ENSP00000429824

    UniGene: Hs.644000