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CLNS1A Antibody

  • 中文名称：
    CLNS1A兔多克隆抗体
  • 货号：
    CSB-PA003782
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of Jurkat cells using pICln Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P54105
  • 基因名：
    CLNS1A
  • 别名：
    Chloride channel antibody; Chloride channel nucleotide sensitive 1A antibody; Chloride channel regulatory protein antibody; Chloride conductance regulator; volume sensitive antibody; Chloride conductance regulatory protein ICln antibody; Chloride ion current inducer protein antibody; ClCI antibody; CLNS 1A antibody; Clns1a antibody; CLNS1B antibody; I(Cln) antibody; ICln antibody; ICLN_HUMAN antibody; Methylosome subunit pICln antibody; nucleotide sensitive 1A antibody; Reticulocyte pICln antibody; Reticulocyte protein ICln antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human pICln.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins. Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.
  • 基因功能参考文献：
    1. the S. pombe ICln protein is required for optimal production of the spliceosomal snRNPs and for efficient splicing in vivo PMID: 24298023
    2. functional interaction between ICln and HSPC038 PMID: 21917931
    3. RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity. PMID: 21081503
    4. revealed an increase of ICln in the mesothelioma cell membrane under hypotonic conditions, an event possibly related to the activation of Cl(-) channels PMID: 14960305
    5. ICln interacts with integrin alphaIIbbeta3 and regulates platelet activation. PMID: 15075326
    6. Data show that ICln159, a truncated ICln mutant, belongs to the pleckstrin homology (PH) domain family of proteins and interacts with LSm4, a protein involved in splicing and mRNA degradation. PMID: 15905169
    7. Lsm10 and Lsm11, which replace the Sm proteins D1 and D2 in the histone RNA processing U7 snRNPs, associate with pICln in vitro and in vivo without receiving sDMA modifications and with PRMT5 and SMN complexes PMID: 16087681

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  • 亚细胞定位：
    Cytoplasm, cytosol. Nucleus. Cytoplasm, cytoskeleton. Note=A small fraction is also associated with the cytoskeleton (PubMed:18984161).
  • 蛋白家族：
    PICln (TC 1.A.47) family
  • 数据库链接：

    HGNC: 2080

    OMIM: 602158

    KEGG: hsa:1207

    STRING: 9606.ENSP00000433919

    UniGene: Hs.430733