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CLPS Antibody

  • 货号：
    CSB-PA005578LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA005578LA01HU diluted at 1:400 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CLPS Polyclonal antibody
  • Uniprot No.：
    P04118
  • 基因名：
    CLPS
  • 别名：
    clpS antibody; COL_HUMAN antibody; Colipase antibody; Colipase pancreatic antibody; Pancreatic colipase preproprotein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Colipase protein (23-112AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CLPS Antibody (CSB-PA005578LA01HU)，的标记方式是Non-conjugated。对于CLPS Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA005578LB01HU CLPS Antibody, HRP conjugated ELISA
    FITC CSB-PA005578LC01HU CLPS Antibody, FITC conjugated
    Biotin CSB-PA005578LD01HU CLPS Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.; Enterostatin has a biological activity as a satiety signal.
  • 基因功能参考文献：
    1. Low CLPS expression is associated with pancreatic cancer. PMID: 23918603
    2. humans with the Arg92Cys substitution will secrete less functional colipase PMID: 23204298
    3. found no evidence for an association of pancreatic colipase(CLPS) single nucleotide polymorphisms rs2766597, rs41270082, rs3748050, and rs3748051 with obesity or percentage of dietary fat intake PMID: 20054203
    4. evidence in two German Caucasian study populations that the variant of the rare colipase Arg109Cys polymorphism might contribute to increased susceptibility of type 2 diabetes PMID: 16189801
    5. Our findings demonstrate that the Arg92Cys polymorphism decreases the function of Cys92 colipase. This change may contribute to the development of type 2 diabetes. PMID: 17715423
    6. CLPS genetic variability associates with insulin secretory function in non-diabetic humans and may represent a novel candidate gene for development of type 2 diabetes PMID: 18726866

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Colipase family
  • 组织特异性：
    Expressed by the pancreas.
  • 数据库链接：

    HGNC: 2085

    OMIM: 120105

    KEGG: hsa:1208

    STRING: 9606.ENSP00000259938

    UniGene: Hs.1340