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CLSTN1 Antibody

  • 货号：
    CSB-PA005588GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O94985
  • 基因名：
    CLSTN1
  • 别名：
    Alc alpha antibody; Alc-alpha antibody; Alcadein alpha 1 antibody; Alcadein alpha antibody; Alcadein-alpha antibody; alcalpha1 antibody; alcalpha2 antibody; Alzheimer related cadherin like protein antibody; Alzheimer-related cadherin-like protein antibody; C-terminal fragment 1-alpha antibody; Cadherin related family member 12 antibody; Calsyntenin 1 antibody; Calsyntenin1 antibody; CDHR12 antibody; CLSTN 1 antibody; Clstn1 antibody; CS1 antibody; CSTN1 antibody; CSTN1_HUMAN antibody; CTF1-alpha antibody; FLJ32258 antibody; KIAA0911 antibody; Non classical cadherin XB31alpha antibody; Non classical cadherin XB31alpha1 antibody; Non-classical cadherin XB31alpha antibody; PIK3CD antibody; SAlc-alpha antibody; XB31alpha antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human CLSTN1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals.
  • 基因功能参考文献：
    1. Results suggests that APP partially compensates for defective Alcalpha in anterograde transport by providing an alternative cargo receptor for kinesin-1. PMID: 29093024
    2. Calsyntenin-1 contributes to the early stages of the hepatitis C virus replication cycle and the formation of the replication complex. PMID: 27221318
    3. Increased plasma p3-Alcalpha35, a major fragment of alcalpha1, may indicate an endophenotype in Alzheimer's disease patients with progressive cognitive impairment. PMID: 24305499
    4. Increased plasma p3-alcadein (alc) alpha, evident in the early stages of cognitive impairment, suggests that alc metabolites are useful plasma biomarkers of Alzheimer's disease. PMID: 22571980
    5. findings show that calsyntenin-1 is reduced in Alzheimer's disease brains and that the extent of this reduction correlates with increased amyloid-beta PMID: 22434822
    6. CLSTN1 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
    7. Phosphorylation of KLC1 at serine 460 modulates binding and trafficking of calsyntenin-1. PMID: 21385839
    8. Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation [alcalpha1, alcbeta, alcgamma] PMID: 15037614

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane. Cell projection, neuron projection. Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein. Nucleus.
  • 组织特异性：
    Expressed in the brain and, a lower level, in the heart, skeletal muscle, kidney and placenta. Accumulates in dystrophic neurites around the amyloid core of Alzheimer disease senile plaques (at protein level).
  • 数据库链接：

    HGNC: 17447

    OMIM: 611321

    KEGG: hsa:22883

    STRING: 9606.ENSP00000366513

    UniGene: Hs.29665