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CNOT7 Antibody

  • 货号：
    CSB-PA001734
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HuvEc cells using CNOT7 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9UIV1
  • 基因名：
    CNOT7
  • 别名：
    BTG1 binding factor 1 antibody; BTG1-binding factor 1 antibody; CAF 1 antibody; CAF-1 antibody; CAF1 antibody; Carbon catabolite repressor protein (CCR4) associative factor 1 antibody; CCR4 associated factor 1 antibody; CCR4 NOT transcription complex subunit 7 antibody; CCR4-associated factor 1 antibody; CCR4-NOT transcription complex subunit 7 antibody; CNOT 7 antibody; Cnot7 antibody; CNOT7_HUMAN antibody; hCAF 1 antibody; hCAF1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human CNOT7.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
  • 基因功能参考文献：
    1. Findings suggest a preferential involvement of CNOT7 variant 2 (CNOT7v2) in nuclear processes, such as arginine methylation and alternative splicing, rather than mRNA turnover PMID: 28591869
    2. MEX3C associates with the cytoplasmic deadenylation complexes and ubiquitinates CNOT7. PMID: 26471122
    3. CNOT7/hCAF1 is involved in ICAM-1 and IL-8 regulation by TTP in HPMEC. PMID: 25038453
    4. CNOT7 is an antimicrobial protein and a regulator of the innate immune response. PMID: 23386060
    5. The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex. PMID: 23236473
    6. CNOT7 is not the target tumor suppressor gene in the 8p22-23.1 colorectal cancer suppressor region. PMID: 12845644
    7. CAF1 is a new regulator of PRMT1-dependent arginine methylation. PMID: 17264152
    8. Data show that Ccr4-Not function in RNA splicing and nuclear export, and that CNOT7 binds strongly with CNOT6. PMID: 19558367
    9. Data show that efficient cell proliferation requires both CNOT7 and CNOT8, although combined knockdown of both subunits further reduces cell proliferation indicating partial redundancy between these proteins. PMID: 19605561

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  • 亚细胞定位：
    Nucleus. Cytoplasm, P-body.
  • 蛋白家族：
    CAF1 family
  • 数据库链接：

    HGNC: 14101

    OMIM: 604913

    KEGG: hsa:29883

    STRING: 9606.ENSP00000355279

    UniGene: Hs.587465