CNPY2 Antibody
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货号:CSB-PA05034A0Rb
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规格:¥440
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促销:
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图片:
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其他:
产品详情
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产品名称:Rabbit anti-Homo sapiens (Human) CNPY2 Polyclonal antibody
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Uniprot No.:Q9Y2B0
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基因名:CNPY2
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别名:Canopy 2 homolog (zebrafish) antibody; Cnpy2 antibody; CNPY2_HUMAN antibody; MIR-interacting saposin-like protein antibody; MSAP antibody; Protein canopy homolog 2 antibody; Putative secreted protein ZSIG9 antibody; TMEM4 antibody; Transmembrane protein 4 antibody; UNQ1943/PRO4426 antibody; ZSIG9 antibody
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宿主:Rabbit
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反应种属:Human
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免疫原:Recombinant Human Protein canopy homolog 2 protein (22-182AA)
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
本页面中的产品,CNPY2 Antibody (CSB-PA05034A0Rb),的标记方式是Non-conjugated。对于CNPY2 Antibody,我们还提供其他标记。见下表:
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克隆类型:Polyclonal
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抗体亚型:IgG
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纯化方式:>95%, Protein G purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
产品提供形式:Liquid
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应用范围:ELISA, WB, IHC
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推荐稀释比:
Application Recommended Dilution WB 1:1000-1:5000 IHC 1:20-1:200 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation.
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基因功能参考文献:
- CNPY2 knockout resulted in the significant suppression of MHCC97H cell proliferation, tumor growth, and hemorrhage. PMID: 30415246
- Overexpression of CNPY2 can activate the AKT/GSK3beta pathway, which leads to the inactivation of GSK-3beta. The inactivation of GSK-3beta increases the level of Snail, and then decreases the expression of E-cadherin to promote EMT. PMID: 29569784
- CNPY2 can serve as a therapeutic target to promote the effect of chemotherapy in non-small cell lung cancer. PMID: 29864955
- CNPY2 isoform2 represents as a novel and valuable prognostic indicator for colorectal cancer patients. PMID: 29135454
- These findings suggested that CNPY2 promoted cancer cell growth in renal cell carcinoma cells through regulating TP53 gene expression. PMID: 28235487
- CNPY2 may play a critical role in colorectal cancer development by enhancing cell proliferation, migration, and angiogenesis and by inhibiting apoptosis through negative regulation of the p53 pathway PMID: 26835537
- CNPY2 is a HIF-1alpha-regulated, secreted angiogenic growth factor that promotes smooth muscle cell migration, proliferation, and tissue revascularization. PMID: 25589425
- Our results are consistent with an important role of FGF21 and Cnpy2/Msap in the regulation of LDLRs in cultured cells. PMID: 22378787
- MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain in fetal and adult brain. PMID: 12826659
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亚细胞定位:Endoplasmic reticulum.
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蛋白家族:Canopy family
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组织特异性:Expressed in different tissues. Highest levels are detected in adult placenta, liver and pancreas.
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数据库链接:
HGNC: 13529
OMIM: 605861
KEGG: hsa:10330
STRING: 9606.ENSP00000273308
UniGene: Hs.8752
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