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CNTN1 Antibody

  • 货号：
    CSB-PA004825
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of mouse brain cells using Contactin 1 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q12860
  • 基因名：
  • 别名：
    CNTN 1 antibody; CNTN antibody; Cntn1 antibody; CNTN1_HUMAN antibody; Contactin-1 antibody; Contactin1 antibody; F3 antibody; F3cam antibody; Glycoprotein gp135 antibody; gp 135 antibody; GP135 antibody; MYPCN antibody; Neural cell surface protein F3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human Contactin 1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth.
  • 基因功能参考文献：
    1. CNTN1 promotes growth, metastasis and invasion of Hs578T breast cancer cell line. PMID: 29673312
    2. Proteolipid protein 1 and contactin 1 gene variation modulates interhemispheric integration PMID: 27864734
    3. CNTN-1 promotes cisplatin resistance in human cisplatin-resistant lung adenocarcinoma through inducing the Epithelial-Mesenchymal Transition process by activating the PI3K/Akt signaling pathway. PMID: 28934754
    4. CNTN1 is a new gene which can be regulated by RET/PTC3 (Ret proto-oncogene and Ret-activating protein ELE1) rearrangement gene and the protein level of CNTN1 is increasing in thyroid cancer. PMID: 26722434
    5. Structurally, CASPR2 is highly glycosylated and has an overall compact architecture. CASPR2 associates with micromolar affinity with CNTN1 but, under the same conditions, it does not interact with any of the other members of the contactin family. PMID: 26721881
    6. CNTN1 promotes prostate cancer progression. PMID: 26795349
    7. High CNTN-1 expression is associated with metastasis in gastric cancer. PMID: 25952582
    8. CNTN-1 is closely related with multidrug resistance of lung adenocarcinoma. PMID: 25960233
    9. anti-CNTN1 IgG4 antibodies are associated with subacute onset of chronic inflammatory demyelinating polyneuropathy symptoms, sensory ataxia, and good response to corticosteroids. PMID: 25808373
    10. under hypoxia conditions, elevated HIF-1alpha seems to up-regulate contactin-1 expression and by this activate RhoA and facilitate migration of cancer cells. PMID: 25916117
    11. a completely novel function for F3/Contactin - modulator of neurogenesis PMID: 22360968
    12. A high expression of CNTN1 was markedly associated with the regional lymph node metastasis of patients with oral squamous cell carcinoma. PMID: 22580838
    13. The expression of CNTN-1 is upregulated in esophageal squamous cell carcinoma tissue and is related to stage and lymphatic invasion. Thus, it may be involved in the pathogenesis & progression of esophageal squamous cell carcinoma. PMID: 22581910
    14. Data revealed that knockdown of VEGFR-3 with the shRNA lentiviral vector resulted in down-regulation of the downstream neural cell adhesion molecule contactin-1 (CNTN-1). PMID: 21805024
    15. report the cocrystal structure of the carbonic anhydrase-like domain of PTPRZ bound to tandem Ig repeats of CNTN1 and binding assays to show that PTPRZ binds specifically to CNTN1 expressed at the surface of oligodendrocyte precursor cells PMID: 21969550
    16. VEGF-C mediated biological function through transcription of CNTN-1, which is implicated in tumor invasion and metastasis. PMID: 21482472
    17. F3 acts as a functional ligand for Notch during oligodendrocyte maturation. PMID: 14567914
    18. The repulsive properties of contactin may be a key factor in glioma disaggregation, and may contribute to the diffuse infiltration pattern characteristic of glioma cells in human brain. PMID: 16078236
    19. Contactin-1 is proposed to function importantly in the invasion and metastasis of lung adenocarcinoma cells via RhoA-mediated mechanisms. PMID: 16510572
    20. Mutations in CNTN1, a neural adhesion molecule and neuromuscular junction protein, cause a familial form of lethal congenital myopathy. PMID: 19026398

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  • 相关疾病：
    Myopathy, congenital, Compton-North (MYPCN)
  • 亚细胞定位：
    [Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.; [Isoform 2]: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.
  • 蛋白家族：
    Immunoglobulin superfamily, Contactin family
  • 组织特异性：
    Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle.
  • 数据库链接：

    HGNC: 2171

    OMIM: 600016

    KEGG: hsa:1272

    STRING: 9606.ENSP00000325660

    UniGene: Hs.143434