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COA6 Antibody

  • 货号：
    CSB-PA683360LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA683360LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) COA6 Polyclonal antibody
  • Uniprot No.：
    Q5JTJ3
  • 基因名：
    COA6
  • 别名：
    COA6 antibody; C1orf31Cytochrome c oxidase assembly factor 6 homolog antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Cytochrome c oxidase assembly factor 6 homolog protein (1-125AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，COA6 Antibody (CSB-PA683360LA01HU)，的标记方式是Non-conjugated。对于COA6 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA683360LB01HU COA6 Antibody, HRP conjugated ELISA
    FITC CSB-PA683360LC01HU COA6 Antibody, FITC conjugated
    Biotin CSB-PA683360LD01HU COA6 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomplexes comprised of complexes III and IV.
  • 基因功能参考文献：
    1. Results find that COA6 associates with COX2 and is crucial for its maturation and complex IV biogenesis. Also, COA6 interacts with the copper chaperone SCO1 which indicates that COA6 is intrinsically involved in the copper delivery process for COX2. PMID: 26160915
    2. Cooperation between COA6 and SCO2 in COX2 maturation during cytochrome c oxidase assembly links two mitochondrial cardiomyopathies. PMID: 25959673
    3. Co-purified with C7orf44 (the human ortholog of fungal COX assembly protein) PMID: 22356826
    4. COX assembly candidate, ortholog of fungal YMR244C-A PMID: 22356826
    5. Strong candidate gene for mitochondrial disease, based on recessive mutations detected in infantile patients PMID: 22277967
    6. Observational study of gene-disease association. (HuGE Navigator) PMID: 20877624

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  • 相关疾病：
    Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 4 (CEMCOX4)
  • 亚细胞定位：
    Mitochondrion intermembrane space.
  • 蛋白家族：
    Cytochrome c oxidase subunit 6B family
  • 数据库链接：

    HGNC: 18025

    OMIM: 614772

    KEGG: hsa:388753

    STRING: 9606.ENSP00000355572

    UniGene: Hs.23198