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COL25A1 Antibody

  • 货号：
    CSB-PA070029
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9BXS0
  • 基因名：
    COL25A1
  • 别名：
    COL25A1Collagen alpha-1(XXV) chain antibody; Alzheimer disease amyloid-associated protein antibody; AMY antibody; CLAC-P) [Cleaved into: Collagen-like Alzheimer amyloid plaque component antibody; CLAC)] antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human COL25A1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.
  • 基因功能参考文献：
    1. We highlight phenotypes of the 4 affected children from the 2 reported families: isolated congenital ptosis (one unilateral, one bilateral) and Duane syndrome (one unilateral, one bilateral) with synergistic divergence. PMID: 26486031
    2. We identified COL25A1 mutations as a cause of autosomal-recessive congenital cranial dysinnervation disorder. PMID: 25500261
    3. COL25A1 methylation correlates with severity of cervical intraepithelial neoplasia PMID: 23018867
    4. The COL25A1 single nucleotide polymorphism rs13134663 was significantly associated with antisocial personality disorder, especially in subjects with comorbid substance dependence. PMID: 22297151
    5. The next best locus for gene x gender interactions for age at onset was in COL25A1 gene at 4q25 PMID: 21688384
    6. provides genetic evidence of association between COL25A1 and risk for Alzheimer's disease PMID: 18501477
    7. COL25A1 leads to Alzheimer's disease-like pathology in vivo PMID: 19548013
    8. CLAC displays features characteristic of a collagen protein, ie. it forms a partly protease-resistant triple-helical structure, exhibits an intermediate affinity for heparin, and is glycosylated; binding domain between CLAC and amyloid beta-peptide PMID: 15522881
    9. CLACbinds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils PMID: 15615705
    10. Results show that collagenous Alzheimer amyloid plaque component (CLAC) assembles amyloid-beta fibrils into fibril bundles that have an increased resistance to proteases. PMID: 15853808
    11. suggest that CLAC becomes involved at an intermediate stage in the pathogenesis of Alzheimer's disease by binding to Abeta fibrils, including fibrils formed from peptides with truncated N- or C-termini, and thereby slows their growth PMID: 16300410

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  • 相关疾病：
    Fibrosis of extraocular muscles, congenital, 5 (CFEOM5)
  • 亚细胞定位：
    Membrane; Single-pass type II membrane protein. Note=After proteolytic cleavage, CLAC is secreted.
  • 组织特异性：
    Expressed predominantly in brain. Deposited preferentially in primitive or neuritic amyloid plaques which are typical of Alzheimer disease.
  • 数据库链接：

    HGNC: 18603

    OMIM: 610004

    KEGG: hsa:84570

    STRING: 9606.ENSP00000382083

    UniGene: Hs.658842