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COPS3 Antibody

  • 货号：
    CSB-PA799923
  • 规格：
    ￥2024
  • 图片：
    • Immunofluorescence analysis of HeLa cells, treated with Forskolin (40nM, 30mins), using JAB1 antibody.
    • Western blot analysis of extracts from LOVO cells, using JAB1 antibody.
    • Western blot analysis of extracts from A549 cells (Lane 2) and HepG2 cells (Lane 3), using JAB1 antiobdy. The lane on the left is treated with systhesized peptide.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) COPS3 Polyclonal antibody
  • Uniprot No.：
    Q9UNS2
  • 基因名：
    COPS3
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human JAB1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IF 1:100-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
  • 基因功能参考文献：
    1. Here the s identify a potential mechanism by which desmosomes assist the de-neddylating COP9 signalosome (CSN) in attenuating EGFR through an association between the Cops3 subunit of the CSN and desmosomal components, Desmoglein1 (Dsg1) and Desmoplakin (Dp), to promote epidermal differentiation. PMID: 28891468
    2. this study demonstrates Csn3 as an oncogene that regulates the tumorigenesis process in hepatocellular carcinoma (HCC) cells. PMID: 22237956
    3. of the COPS3 gene might have important roles in metastasis of osteosarcoma cells. PMID: 21436869
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    CSN3 family
  • 组织特异性：
    Widely expressed. Expressed at high level in heart and skeletal muscle.
  • 数据库链接：

    HGNC: 2239

    OMIM: 604665

    KEGG: hsa:8533

    STRING: 9606.ENSP00000268717

    UniGene: Hs.6076