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COPS4 Antibody

  • 货号：
    CSB-PA880098ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: COPS4 antibody at 8μg/ml
      Lane 1: Hela whole cell lysate
      Lane 2: HepG2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 47, 41 kDa
      Observed band size: 47 kDa
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA880098ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA880098ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) COPS4 Polyclonal antibody
  • Uniprot No.：
    Q9BT78
  • 基因名：
    COPS4
  • 别名：
    CH4 antibody; COP9 (constitutive photomorphogenic) homolog subunit 4 antibody; COP9 complex homolog subunit 4 antibody; COP9 complex S4 antibody; COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) antibody; COP9 constitutive photomorphogenic homolog subunit 4 antibody; COP9 signalosome complex subunit 4 antibody; COP9 signalosome subunit 4 antibody; COPS4 antibody; CSN complex subunit 4 antibody; CSN4 antibody; CSN4 SCHPO antibody; CSN4_HUMAN antibody; DCH4 antibody; JAB1 containing signalosome subunit 4 antibody; JAB1-containing signalosome subunit 4 antibody; MGC94896 antibody; SGN4 antibody; Signalosome subunit 4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human COP9 signalosome complex subunit 4 protein (1-310AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:200-1:1000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
  • 基因功能参考文献：
    1. Identified is a novel-binding partner of torsin A, the subunit 4 (CSN4) of CSN signalosome. PMID: 21102408
    2. Level in fetal Down syndrome brain found to be comparable to that of controls. PMID: 11824616
  • 亚细胞定位：
    Cytoplasm. Nucleus. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.
  • 蛋白家族：
    CSN4 family
  • 数据库链接：

    HGNC: 16702

    OMIM: 616008

    KEGG: hsa:51138

    STRING: 9606.ENSP00000264389

    UniGene: Hs.190384