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  4. COPS6 Antibody

COPS6 Antibody

  • 货号：
    CSB-PA005793GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q7L5N1
  • 基因名：
    COPS6
  • 别名：
    COP9 (constitutive photomorphogenic); subunit 6; COP9 complex S6 antibody; COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis) antibody; COP9 signalosome complex subunit 6 antibody; COP9 signalosome subunit 6 antibody; COP9 subunit 6 (MOV34 homolog; 34 kD) antibody; cops6 antibody; CSN6 antibody; CSN6_HUMAN antibody; H_NH0506M12.12 antibody; hVIP antibody; JAB1 containing signalosome subunit 6 antibody; JAB1-containing signalosome subunit 6 antibody; MOV34 homolog antibody; MOV34 homolog; 34 kD antibody; MOV34-34KD antibody; OTTMUSP00000025868 antibody; Sgn3 antibody; SGN6 antibody; Signalosome subunit 6 antibody; VIP/MOV34 antibody; Vpr interacting protein antibody; Vpr-interacting protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human COPS6
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets.
  • 基因功能参考文献：
    1. High CSN6 expression is associated with metastasis of glioblastoma. PMID: 27546621
    2. The overexpression of CSN6 reduced the effect of quercetin treatment on HT29 cells, suggesting that quercetininduced apoptosis may involve the AktCSN6Myc signaling axis in HT29 cells. PMID: 27748879
    3. CSN6 positively regulates c-Jun in a MEKK1-dependent manner PMID: 26237449
    4. our results indicate that CSN6 is a positive regulator of E6AP and is important for cervical cancer development. PMID: 26318036
    5. CSN6 interacts with p27(Kip1) and facilitates ubiquitin-mediated degradation of p27(Kip1). PMID: 25945542
    6. Findings indicate that the deregulation of beta-catenin by extracellular signal-regulated kinase 2 (ERK2)-activated CSN6 protein is important for colorectal cancer (CRC) development. PMID: 26267535
    7. Analyses of the pseudo metal-binding motif in CSN6 suggest that the loss of two key histidine residues may contribute to the lack of catalytic activity in CSN6. PMID: 25242525
    8. Data suggest that CSN6 is an important negative regulator of p57 (Kip2) , and that overexpression of CSN6 in many types of cancer could lead to decreased expression of p57 (Kip2) and result in promoted cancer cell growth. PMID: 23187808
    9. COPS6 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
    10. loss of CSN6 enhances p53-mediated tumor suppression in vivo and CSN6 plays an important role in regulating DNA damage-associated apoptosis and tumorigenesis through control of the MDM2-p53 signaling pathway PMID: 21317535
    11. critical role of caspase 8 in the processing of CSN6. PMID: 17337451
    12. For the first time our data demonstrate that CSN-mediated deneddylation can be regulated by active Casp3 and that the CSN executes a specific function during the apoptotic process. PMID: 18060501

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  • 亚细胞定位：
    Nucleus. Cytoplasm.; Cytoplasm, perinuclear region.
  • 蛋白家族：
    Peptidase M67A family, CSN6 subfamily
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 21749

    OMIM: 614729

    KEGG: hsa:10980

    STRING: 9606.ENSP00000304102

    UniGene: Hs.15591