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COQ8B Antibody

  • 货号：
    CSB-PA839305LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, A549 whole cell lysate, HepG2 whole cell lysate
      All lanes: COQ8B antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 61, 56 kDa
      Observed band size: 61, 56 kDa
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA839305LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA839305LA01HU at dilution of 1:100
    • Immunofluorescent analysis of A549 cells using CSB-PA839305LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) COQ8B Polyclonal antibody
  • Uniprot No.：
    Q96D53
  • 基因名：
    COQ8B
  • 别名：
    COQ8B; ADCK4; Atypical kinase COQ8B, mitochondrial; AarF domain-containing protein kinase 4; Coenzyme Q protein 8B
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Atypical kinase COQ8B, mitochondrial protein (10-137AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，COQ8B Antibody (CSB-PA839305LA01HU)，的标记方式是Non-conjugated。对于COQ8B Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA839305LB01HU COQ8B Antibody, HRP conjugated ELISA
    FITC CSB-PA839305LC01HU COQ8B Antibody, FITC conjugated
    Biotin CSB-PA839305LD01HU COQ8B Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is unclear: does not show any protein kinase activity. Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway. Required for podocyte migration.
  • 基因功能参考文献：
    1. Mutations in ADCK4 resulted in reduced CoQ10 levels and reduced mitochondrial respiratory enzyme activity in cells isolated from individuals with steroid-resistant nephrotic syndrome & transformed lymphoblasts. PMID: 24270420
  • 相关疾病：
    Nephrotic syndrome 9 (NPHS9)
  • 亚细胞定位：
    Mitochondrion membrane; Single-pass membrane protein. Cytoplasm, cytosol. Cell membrane.
  • 蛋白家族：
    Protein kinase superfamily, ADCK protein kinase family
  • 组织特异性：
    Widely expressed, including renal podocytes.
  • 数据库链接：

    HGNC: 19041

    OMIM: 615567

    KEGG: hsa:79934

    STRING: 9606.ENSP00000315118

    UniGene: Hs.130712